Pathology of Cardiac Transplantation

C. D. Tan, M. K. Halushka, E. R. Rodriguez

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiac transplantation offers an effective therapeutic option for patients with end-stage heart failure. The success of cardiac transplantation has been attributed to the refinement in the criteria for recipient and donor selections, better monitoring for rejection through endomyocardial biopsies, and improved immunosuppression regimens. This chapter emphasizes the histopathologic evaluation of the explanted heart, the allograft through its natural history, and the failed allograft. The diagnostic interpretation and reporting of rejection in surveillance endomyocardial biopsies in accordance with the International Society for Heart and Lung Transplantation working formulations for cellular and antibody-mediated rejection (AMR) are presented. Since the last edition of this textbook, AMR has gained recognition as an important cause of cardiac allograft dysfunction. Current concepts and controversies in AMR including the proposed grading system for pathologic AMR are discussed. Commonly encountered nonrejection biopsy findings are also illustrated. The major causes of graft failure and death in transplant patients, particularly cardiac allograft vasculopathy, are reviewed.

Original languageEnglish (US)
Title of host publicationCardiovascular Pathology
Subtitle of host publicationFourth Edition
PublisherElsevier Inc.
Pages679-719
Number of pages41
ISBN (Electronic)9780128004593
ISBN (Print)9780124202191
DOIs
StatePublished - Jan 1 2016

Keywords

  • Acute cellular rejection
  • Antibody-mediated rejection
  • Cardiac allograft vasculopathy
  • Cardiac transplantation
  • Complement activation
  • Donor-specific antibodies
  • Endomyocardial biopsy

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Tan, C. D., Halushka, M. K., & Rodriguez, E. R. (2016). Pathology of Cardiac Transplantation. In Cardiovascular Pathology: Fourth Edition (pp. 679-719). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-420219-1.00016-1