Pathology and molecular genetics of pancreatic neoplasms

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer is fundamentally a genetic disease caused by the accumulation of somatic mutations in oncogenes and tumor suppressor genes. In the last decade, rapid advances in sequencing and bioinformatic technology led to an explosion in sequencing studies of cancer genomes, greatly expanding our knowledge of the genetic changes underlying a variety of tumor types. Several of these studies of cancer genomes have focused on pancreatic neoplasms, and cancers from the pancreas are some of the best characterized tumors at the genetic level. Pancreatic neoplasms encompass a wide array of clinical diseases, from benign cysts to deadly cancers, and the genetic alterations underlying neoplasms of the pancreas are similarly diverse. This new knowledge of pancreatic cancer genomes has deepened our understanding of tumorigenesis in the pancreas and has opened several promising new avenues for novel diagnostics and therapeutics.

Original languageEnglish (US)
Pages (from-to)492-501
Number of pages10
JournalCancer Journal (United States)
Volume18
Issue number6
DOIs
StatePublished - Nov 2012

Keywords

  • Pancreatic neoplasms
  • pancreatic cancer genomes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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