Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

D. Balmativola, C. Marchiò, M. Maule, L. Chiusa, L. Annaratone, F. Maletta, F. Montemurro, J. Kulka, P. Figueiredo, Z. Varga, I. Liepniece-Karele, G. Cserni, E. Arkoumani, I. Amendoeira, G. Callagy, A. Reiner-Concin, A. Cordoba, S. Bianchi, T. Decker, D. GläserC. Focke, P. van Diest, D. Grabau, E. Lips, J. Wesseling, R. Arisio, E. Medico, C. Wells, A. Sapino

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p 2 and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and 

Original languageEnglish (US)
Pages (from-to)511-523
Number of pages13
JournalBreast Cancer Research and Treatment
Issue number3
StatePublished - Nov 25 2014
Externally publishedYes


  • Breast cancer
  • Mitotic count
  • Neoadjuvant therapy
  • Non-response
  • Proliferation

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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