Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

D. Balmativola; C. Marchiò; M. Maule; L. Chiusa; L. Annaratone; F. Maletta; F. Montemurro; J. Kulka; P. Figueiredo; Z. Varga; I. Liepniece-Karele; G. Cserni; E. Arkoumani; I. Amendoeira; G. Callagy; A. Reiner-Concin; A. Cordoba; S. Bianchi; T. Decker; D. Gläser; C. Focke; P. van Diest; D. Grabau; E. Lips; J. Wesseling; R. Arisio; E. Medico; C. Wells; A. Sapino

doi:10.1007/s10549-014-3192-3

Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

D. Balmativola, C. Marchiò, M. Maule, L. Chiusa, L. Annaratone, F. Maletta, F. Montemurro, J. Kulka, P. Figueiredo, Z. Varga, I. Liepniece-Karele, G. Cserni, E. Arkoumani, I. Amendoeira, G. Callagy, A. Reiner-Concin, A. Cordoba, S. Bianchi, T. Decker, D. GläserC. Focke, P. van Diest, D. Grabau, E. Lips, J. Wesseling, R. Arisio, E. Medico, C. Wells, A. Sapino

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p 2 and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and

Original language	English (US)
Pages (from-to)	511-523
Number of pages	13
Journal	Breast Cancer Research and Treatment
Volume	148
Issue number	3
DOIs	https://doi.org/10.1007/s10549-014-3192-3
State	Published - Nov 25 2014
Externally published	Yes

Keywords

Breast cancer
Mitotic count
Neoadjuvant therapy
Non-response
Proliferation

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1007/s10549-014-3192-3

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Balmativola, D., Marchiò, C., Maule, M., Chiusa, L., Annaratone, L., Maletta, F., Montemurro, F., Kulka, J., Figueiredo, P., Varga, Z., Liepniece-Karele, I., Cserni, G., Arkoumani, E., Amendoeira, I., Callagy, G., Reiner-Concin, A., Cordoba, A., Bianchi, S., Decker, T., ... Sapino, A. (2014). Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study. Breast Cancer Research and Treatment, 148(3), 511-523. https://doi.org/10.1007/s10549-014-3192-3

Balmativola, D, Marchiò, C, Maule, M, Chiusa, L, Annaratone, L, Maletta, F, Montemurro, F, Kulka, J, Figueiredo, P, Varga, Z, Liepniece-Karele, I, Cserni, G, Arkoumani, E, Amendoeira, I, Callagy, G, Reiner-Concin, A, Cordoba, A, Bianchi, S, Decker, T, Gläser, D, Focke, C, van Diest, P, Grabau, D, Lips, E, Wesseling, J, Arisio, R, Medico, E, Wells, C & Sapino, A 2014, 'Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study', Breast Cancer Research and Treatment, vol. 148, no. 3, pp. 511-523. https://doi.org/10.1007/s10549-014-3192-3

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abstract = "To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p 2 and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and ",

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T2 - an inter-institutional study

AU - Balmativola, D.

AU - Marchiò, C.

AU - Maule, M.

AU - Chiusa, L.

AU - Annaratone, L.

AU - Maletta, F.

AU - Montemurro, F.

AU - Kulka, J.

AU - Figueiredo, P.

AU - Varga, Z.

AU - Liepniece-Karele, I.

AU - Cserni, G.

AU - Arkoumani, E.

AU - Amendoeira, I.

AU - Callagy, G.

AU - Reiner-Concin, A.

AU - Cordoba, A.

AU - Bianchi, S.

AU - Decker, T.

AU - Gläser, D.

AU - Focke, C.

AU - van Diest, P.

AU - Grabau, D.

AU - Lips, E.

AU - Wesseling, J.

AU - Arisio, R.

AU - Medico, E.

AU - Wells, C.

AU - Sapino, A.

PY - 2014/11/25

Y1 - 2014/11/25

N2 - To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p 2 and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and

AB - To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic count; tumor-infiltrating lymphocytes; necrosis) and data regarding the pathological response in corresponding surgical resection specimens. Analyses were carried out in a cohort of 490 cases by comparing the groups of patients showing pathological complete response (pCR) and partial response (pPR) with the group of non-responders (pathological non-response: pNR). Among other parameters, the lobular histotype and the absence of inflammation were significantly more common in pNR (p 2 and 18 % of Ki67-positive cells best discriminated the pNR and pCR + pPR categories (p = 0.018 and

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KW - Mitotic count

KW - Neoadjuvant therapy

KW - Non-response

KW - Proliferation

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Pathological non-response to chemotherapy in a neoadjuvant setting of breast cancer: an inter-institutional study

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