Pathological laughter and crying and psychiatric comorbidity after traumatic brain injury

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Abstract

There are limited data regarding the incidence of pathological laughter and crying (PLC) after traumatic brain injury (TBI). This study aimed to identify the occurrence of PLC in the first year after TBI and to determine whether there is a relationship between PLC and other clinical features or demographics. Subjects who sustained a first-time TBI were recruited fromacute trauma units and were assessed at 3, 6, and 12 months after TBI. Rates of PLC at 3, 6, and 12 months after TBI were 21.4%, 17.5%, and 15.5%, respectively. Patients with PLC had higher percentages of psychiatric diagnoses, including personality changes, depressive disorders, andmood disorders secondary to a general medical condition, as well as higher rates of posttraumatic stress disorder. Univariate logistic and linear regression analyses indicated a significant association between PLCand scores on theClinical Anxiety Scale 3 months after TBI and on the Hamilton Depression Rating Scale 12months after TBI. Individuals who have PLC during the first year after TBI are more likely to have any psychiatric diagnosis as well as higher rates of mood and anxiety symptoms. In addition, PLC in the early TBI period may serve as a predictor of depression and anxiety symptoms at 12 months after TBI.

Original languageEnglish (US)
Pages (from-to)299-303
Number of pages5
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Volume27
Issue number4
DOIs
StatePublished - Sep 1 2015

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Laughter
Crying
Psychiatry
Comorbidity
Anxiety
Mental Disorders
Traumatic Brain Injury
Depression
Trauma Centers
Depressive Disorder
Post-Traumatic Stress Disorders
Personality
Linear Models
Logistic Models
Regression Analysis
Demography

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Clinical Neurology

Cite this

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title = "Pathological laughter and crying and psychiatric comorbidity after traumatic brain injury",
abstract = "There are limited data regarding the incidence of pathological laughter and crying (PLC) after traumatic brain injury (TBI). This study aimed to identify the occurrence of PLC in the first year after TBI and to determine whether there is a relationship between PLC and other clinical features or demographics. Subjects who sustained a first-time TBI were recruited fromacute trauma units and were assessed at 3, 6, and 12 months after TBI. Rates of PLC at 3, 6, and 12 months after TBI were 21.4{\%}, 17.5{\%}, and 15.5{\%}, respectively. Patients with PLC had higher percentages of psychiatric diagnoses, including personality changes, depressive disorders, andmood disorders secondary to a general medical condition, as well as higher rates of posttraumatic stress disorder. Univariate logistic and linear regression analyses indicated a significant association between PLCand scores on theClinical Anxiety Scale 3 months after TBI and on the Hamilton Depression Rating Scale 12months after TBI. Individuals who have PLC during the first year after TBI are more likely to have any psychiatric diagnosis as well as higher rates of mood and anxiety symptoms. In addition, PLC in the early TBI period may serve as a predictor of depression and anxiety symptoms at 12 months after TBI.",
author = "Durga Roy and McCann, {Una D} and Dingfen Han and Rao, {Vani A}",
year = "2015",
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AU - Rao, Vani A

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N2 - There are limited data regarding the incidence of pathological laughter and crying (PLC) after traumatic brain injury (TBI). This study aimed to identify the occurrence of PLC in the first year after TBI and to determine whether there is a relationship between PLC and other clinical features or demographics. Subjects who sustained a first-time TBI were recruited fromacute trauma units and were assessed at 3, 6, and 12 months after TBI. Rates of PLC at 3, 6, and 12 months after TBI were 21.4%, 17.5%, and 15.5%, respectively. Patients with PLC had higher percentages of psychiatric diagnoses, including personality changes, depressive disorders, andmood disorders secondary to a general medical condition, as well as higher rates of posttraumatic stress disorder. Univariate logistic and linear regression analyses indicated a significant association between PLCand scores on theClinical Anxiety Scale 3 months after TBI and on the Hamilton Depression Rating Scale 12months after TBI. Individuals who have PLC during the first year after TBI are more likely to have any psychiatric diagnosis as well as higher rates of mood and anxiety symptoms. In addition, PLC in the early TBI period may serve as a predictor of depression and anxiety symptoms at 12 months after TBI.

AB - There are limited data regarding the incidence of pathological laughter and crying (PLC) after traumatic brain injury (TBI). This study aimed to identify the occurrence of PLC in the first year after TBI and to determine whether there is a relationship between PLC and other clinical features or demographics. Subjects who sustained a first-time TBI were recruited fromacute trauma units and were assessed at 3, 6, and 12 months after TBI. Rates of PLC at 3, 6, and 12 months after TBI were 21.4%, 17.5%, and 15.5%, respectively. Patients with PLC had higher percentages of psychiatric diagnoses, including personality changes, depressive disorders, andmood disorders secondary to a general medical condition, as well as higher rates of posttraumatic stress disorder. Univariate logistic and linear regression analyses indicated a significant association between PLCand scores on theClinical Anxiety Scale 3 months after TBI and on the Hamilton Depression Rating Scale 12months after TBI. Individuals who have PLC during the first year after TBI are more likely to have any psychiatric diagnosis as well as higher rates of mood and anxiety symptoms. In addition, PLC in the early TBI period may serve as a predictor of depression and anxiety symptoms at 12 months after TBI.

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