Pathological characteristics and radiographic correlates of complex renal cysts

Research output: Contribution to journalArticle

Abstract

Objectives: To characterize pathological and cancer-specific outcomes of surgically resected cystic renal tumors and to identify clinical or radiographic features associated with these outcomes. Methods and materials: All patients at our institution who underwent radical or partial nephrectomy for complex renal cystic masses between 2004 and 2011 with available computed tomographic imaging were included. The Bosniak score was determined, as were 10 specific radiographic characteristics of renal cysts in patients with preoperative imaging available for review. These characteristics were correlated with cystic mass histopathology. Recurrence-free survival after surgery was determined. Results: Overall, 133 patients underwent renal surgery for complex cystic lesions, 89 (67%) of whom had malignant lesions. Malignancy risk increased with Bosniak score (P≤0.01) and presence of mural nodules (P = 0.01). Most (63%) malignancies demonstrated clear cell histology. The papillary renal cell carcinomas (25%) exhibited lower enhancement levels (P = 0.04) and were less often septated (P

Original languageEnglish (US)
Pages (from-to)1010-1016
Number of pages7
JournalUrologic Oncology: Seminars and Original Investigations
Volume32
Issue number7
DOIs
StatePublished - Oct 1 2014

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Cysts
Kidney
Neoplasms
Nephrectomy
Renal Cell Carcinoma
Histology
Recurrence
Survival

Keywords

  • Cysts
  • Kidney
  • Renal cell carcinoma
  • X-ray computed tomography

ASJC Scopus subject areas

  • Oncology
  • Urology

Cite this

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title = "Pathological characteristics and radiographic correlates of complex renal cysts",
abstract = "Objectives: To characterize pathological and cancer-specific outcomes of surgically resected cystic renal tumors and to identify clinical or radiographic features associated with these outcomes. Methods and materials: All patients at our institution who underwent radical or partial nephrectomy for complex renal cystic masses between 2004 and 2011 with available computed tomographic imaging were included. The Bosniak score was determined, as were 10 specific radiographic characteristics of renal cysts in patients with preoperative imaging available for review. These characteristics were correlated with cystic mass histopathology. Recurrence-free survival after surgery was determined. Results: Overall, 133 patients underwent renal surgery for complex cystic lesions, 89 (67{\%}) of whom had malignant lesions. Malignancy risk increased with Bosniak score (P≤0.01) and presence of mural nodules (P = 0.01). Most (63{\%}) malignancies demonstrated clear cell histology. The papillary renal cell carcinomas (25{\%}) exhibited lower enhancement levels (P = 0.04) and were less often septated (P",
keywords = "Cysts, Kidney, Renal cell carcinoma, X-ray computed tomography",
author = "Reese, {Adam C.} and Pamela Johnson and Michael Gorin and Pierorazio, {Phillip Martin} and Allaf, {Mohamad E} and Fishman, {Elliot K} and Netto, {George J.} and Christian Pavlovich",
year = "2014",
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doi = "10.1016/j.urolonc.2014.02.022",
language = "English (US)",
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TY - JOUR

T1 - Pathological characteristics and radiographic correlates of complex renal cysts

AU - Reese, Adam C.

AU - Johnson, Pamela

AU - Gorin, Michael

AU - Pierorazio, Phillip Martin

AU - Allaf, Mohamad E

AU - Fishman, Elliot K

AU - Netto, George J.

AU - Pavlovich, Christian

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objectives: To characterize pathological and cancer-specific outcomes of surgically resected cystic renal tumors and to identify clinical or radiographic features associated with these outcomes. Methods and materials: All patients at our institution who underwent radical or partial nephrectomy for complex renal cystic masses between 2004 and 2011 with available computed tomographic imaging were included. The Bosniak score was determined, as were 10 specific radiographic characteristics of renal cysts in patients with preoperative imaging available for review. These characteristics were correlated with cystic mass histopathology. Recurrence-free survival after surgery was determined. Results: Overall, 133 patients underwent renal surgery for complex cystic lesions, 89 (67%) of whom had malignant lesions. Malignancy risk increased with Bosniak score (P≤0.01) and presence of mural nodules (P = 0.01). Most (63%) malignancies demonstrated clear cell histology. The papillary renal cell carcinomas (25%) exhibited lower enhancement levels (P = 0.04) and were less often septated (P

AB - Objectives: To characterize pathological and cancer-specific outcomes of surgically resected cystic renal tumors and to identify clinical or radiographic features associated with these outcomes. Methods and materials: All patients at our institution who underwent radical or partial nephrectomy for complex renal cystic masses between 2004 and 2011 with available computed tomographic imaging were included. The Bosniak score was determined, as were 10 specific radiographic characteristics of renal cysts in patients with preoperative imaging available for review. These characteristics were correlated with cystic mass histopathology. Recurrence-free survival after surgery was determined. Results: Overall, 133 patients underwent renal surgery for complex cystic lesions, 89 (67%) of whom had malignant lesions. Malignancy risk increased with Bosniak score (P≤0.01) and presence of mural nodules (P = 0.01). Most (63%) malignancies demonstrated clear cell histology. The papillary renal cell carcinomas (25%) exhibited lower enhancement levels (P = 0.04) and were less often septated (P

KW - Cysts

KW - Kidney

KW - Renal cell carcinoma

KW - X-ray computed tomography

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