Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh; Petra Houbova; Rudolph J. Castellani; Fausto J. Rodriguez; Minesh P. Mehta; Graeme F. Woodworth

doi:10.1016/j.jocn.2016.01.022

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh, Petra Houbova, Rudolph J. Castellani, Fausto J. Rodriguez, Minesh P. Mehta, Graeme F. Woodworth

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

Original language	English (US)
Pages (from-to)	143-145
Number of pages	3
Journal	Journal of Clinical Neuroscience
Volume	30
DOIs	https://doi.org/10.1016/j.jocn.2016.01.022
State	Published - Aug 1 2016

Keywords

Amyloid
Immunoglobulin
Mass spectrometry

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2016.01.022

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title = "Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits",

abstract = "We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.",

keywords = "Amyloid, Immunoglobulin, Mass spectrometry",

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AU - Hersh, David S.

AU - Houbova, Petra

AU - Castellani, Rudolph J.

AU - Rodriguez, Fausto J.

AU - Mehta, Minesh P.

AU - Woodworth, Graeme F.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

AB - We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

KW - Amyloid

KW - Immunoglobulin

KW - Mass spectrometry

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JO - Journal of Clinical Neuroscience

JF - Journal of Clinical Neuroscience

ER -

Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

Abstract

Keywords

ASJC Scopus subject areas

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