Pathologic deposition of non-amyloid immunoglobulin in the brain leading to mass effect and neurological deficits

David S. Hersh, Petra Houbova, Rudolph J. Castellani, Fausto J. Rodriguez, Minesh P. Mehta, Graeme F. Woodworth

Research output: Contribution to journalArticlepeer-review

Abstract

We report a 31-year-old man with multiple large, non-enhancing intracerebral lesions exerting significant mass effect. Following debulking, histopathological analysis revealed abundant amorphous non-amyloid eosinophilic material, while liquid chromatography mass spectrometry revealed κ light chains and immunoglobulin A heavy chains, leading to the diagnosis of multiple intracerebral light-and-heavy chain aggregomas. Localized intracranial deposits of non-amyloid immunoglobulin may rarely mimic space-occupying intracranial neoplasms and should be considered in the differential diagnosis.

Original languageEnglish (US)
Pages (from-to)143-145
Number of pages3
JournalJournal of Clinical Neuroscience
Volume30
DOIs
StatePublished - Aug 1 2016

Keywords

  • Amyloid
  • Immunoglobulin
  • Mass spectrometry

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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