Pathologic and clinical characteristics of early onset renal cell carcinoma

Tyler Clemmensen, Andres Matoso, Tiffany Graham, Win Shun Lai, Soroush Rais-Bahrami, Jennifer Gordetsky

Research output: Contribution to journalArticle

Abstract

The majority of renal cell carcinomas (RCCs) occur within the 7th decade of life, uncommonly arising in adults ≤46 years. We reviewed the clinicopathologic features of early onset RCC and evaluated the role of immunohistochemistry (IHC) in potentially identifying diagnoses of newly recognized RCC subtypes that may have been previously misclassified. A retrospective review was performed from 2011–2016 for cases of RCC. Early onset RCC was defined as ≤46 years of age. Clinicopathologic findings and hematoxylin and eosin (H&E) slides were reviewed on early onset RCC patients. IHC was performed on all cases previously diagnosed as unclassified or papillary. Clinicopathologic findings were compared to a control group of RCC patients >46 years over the same time period. We identified 98/598 (16.4%) early onset RCCs. The median age in the early onset RCC and control group was 38.4 and 62.8 years, respectively. The early onset RCC group contained 33/96 (34.3%) females and 63/96 (65.6%) males, including 52/96 (54.2%) whites, 39/96 (40.6%) African Americans, 4/96 (4.2%) Hispanics, and 1/96 (1%) Asian. Nonwhites were significantly more likely to develop early onset RCC (P =.004). Early onset RCCs included 52% clear cell, 28.6% papillary, 8.2% unclassified, 5.1% chromophobe, 3.1% clear cell papillary(CCP), and 3 other rare tumors. Six unclassified and 26 papillary RCCs had tissue available for IHC. Two of 6 (33.3%) unclassified RCCs were reclassified (1 CCP, 1 Xp11 translocation). One of 26 (3.8%) papillary RCCs was reclassified as CCP. Early onset RCCs were more likely to occur in nonwhites (P =.004), be lower stage (P =.03), and undergo partial nephrectomy (P =.002). Few unclassified and papillary tumors were reclassified with IHC.

Original languageEnglish (US)
Pages (from-to)25-31
Number of pages7
JournalHuman Pathology
Volume74
DOIs
StatePublished - Apr 1 2018

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Renal Cell Carcinoma
Immunohistochemistry
Control Groups
Hematoxylin
Eosine Yellowish-(YS)
Nephrectomy
Hispanic Americans
African Americans
Neoplasms

Keywords

  • Cancer grading
  • Cancer staging
  • Early onset
  • Radical nephrectomy
  • Renal cell carcinoma
  • Renal tumor

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathologic and clinical characteristics of early onset renal cell carcinoma. / Clemmensen, Tyler; Matoso, Andres; Graham, Tiffany; Lai, Win Shun; Rais-Bahrami, Soroush; Gordetsky, Jennifer.

In: Human Pathology, Vol. 74, 01.04.2018, p. 25-31.

Research output: Contribution to journalArticle

Clemmensen, T, Matoso, A, Graham, T, Lai, WS, Rais-Bahrami, S & Gordetsky, J 2018, 'Pathologic and clinical characteristics of early onset renal cell carcinoma', Human Pathology, vol. 74, pp. 25-31. https://doi.org/10.1016/j.humpath.2017.11.005
Clemmensen, Tyler ; Matoso, Andres ; Graham, Tiffany ; Lai, Win Shun ; Rais-Bahrami, Soroush ; Gordetsky, Jennifer. / Pathologic and clinical characteristics of early onset renal cell carcinoma. In: Human Pathology. 2018 ; Vol. 74. pp. 25-31.
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