TY - JOUR
T1 - Pathogenomics of Culex quinquefasciatus and meta-analysis of infection responses to diverse pathogens
AU - Bartholomay, Lyric C.
AU - Waterhouse, Robert M.
AU - Mayhew, George F.
AU - Campbell, Corey L.
AU - Michel, Kristin
AU - Zou, Zhen
AU - Ramirez, Jose L.
AU - Das, Suchismita
AU - Alvarez, Kanwal
AU - Arensburger, Peter
AU - Bryant, Bart
AU - Chapman, Sinead B.
AU - Dong, Yuemei
AU - Erickson, Sara M.
AU - Parakrama Karunaratne, S. H.P.
AU - Kokoza, Vladimir
AU - Kodira, Chinnappa D.
AU - Pignatelli, Patricia
AU - Shin, Sang Woon
AU - Vanlandingham, Dana L.
AU - Atkinson, Peter W.
AU - Birren, Bruce
AU - Christophides, George K.
AU - Clem, Rollie J.
AU - Hemingway, Janet
AU - Higgs, Stephen
AU - Megy, Karine
AU - Ranson, Hilary
AU - Zdobnov, Evgeny M.
AU - Raikhel, Alexander S.
AU - Christensen, Bruce M.
AU - Dimopoulos, George
AU - Muskavitch, Marc A.T.
PY - 2010/10/1
Y1 - 2010/10/1
N2 - The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
AB - The mosquito Culex quinquefasciatus poses a substantial threat to human and veterinary health as a primary vector of West Nile virus (WNV), the filarial worm Wuchereria bancrofti, and an avian malaria parasite. Comparative phylogenomics revealed an expanded canonical C. quinquefasciatus immune gene repertoire compared with those of Aedes aegypti and Anopheles gambiae. Transcriptomic analysis of C. quinquefasciatus genes responsive to WNV, W. bancrofti, and non-native bacteria facilitated an unprecedented meta-analysis of 25 vector-pathogen interactions involving arboviruses, filarial worms, bacteria, and malaria parasites, revealing common and distinct responses to these pathogen types in three mosquito genera. Our findings provide support for the hypothesis that mosquito-borne pathogens have evolved to evade innate immune responses in three vector mosquito species of major medical importance.
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U2 - 10.1126/science.1193162
DO - 10.1126/science.1193162
M3 - Article
C2 - 20929811
AN - SCOPUS:77957361060
SN - 0036-8075
VL - 330
SP - 88
EP - 90
JO - Science
JF - Science
IS - 6000
ER -