Pathogenetic role for early focal macrophage infiltration in a pig model of arteriovenous fistula (AVF) stenosis

Prabir Roy-Chaudhury, Rao Khan, Begoña Campos, Yang Wang, Michelle Kurian, Timmy Lee, Lois Arend, Rino Munda

Research output: Contribution to journalArticle

Abstract

Purpose: Arteriovenous fistula non-maturation because of a peri-anastomotic venous stenosis is currently a huge clinical problem for which there are no effective therapies. Methods: In an attempt to further define the cellular pathways involved in this process we have assessed the pattern and intensity of macrophage infiltration at different time points in a pig model of AVF stenosis. Results: Our results demonstrate an early and eccentric pattern of macrophage infiltration at 2d with a rapid disappearance of this infiltrate by 7d. Conclusion: We suggest that this early and eccentric macrophage infiltration could play an important role in the pathogenesis of AVF non-maturation.

Original languageEnglish (US)
Pages (from-to)25-28
Number of pages4
JournalJournal of Vascular Access
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Arteriovenous fistula
  • Infiltration
  • Macrophage
  • Pig
  • Stenosis

ASJC Scopus subject areas

  • Surgery
  • Nephrology

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