TY - JOUR
T1 - Pathogenesis of testicular germ cell neoplasia
T2 - A conceptual approach
AU - Baraban, Ezra G.
AU - Cooper, Kumarasen
N1 - Publisher Copyright:
© 2019 Wolters Kluwer Health, Inc. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Testicular germ cell tumors are a diverse group of neoplasms, consisting of the prepubertal type 1 tumors, pure teratoma, and pure yolk sac tumor, the type 2 tumors, which are biologically malignant, preceded by germ cell neoplasia in situ, and harbor chromosome 12p abnormalities, and the type 3 tumor, spermatocytic tumor, which features chromosome 9p amplification.1 These arise in distinct clinical settings, and harbor distinct genetic abnormalities, immunohistochemical properties, and morphologic features. Here we have attempted to unify embryology, morphology, immunohistochemistry, and genetics in order to distill this fascinating group of neoplasms into what we hope is a useful framework for understanding their classification.
AB - Testicular germ cell tumors are a diverse group of neoplasms, consisting of the prepubertal type 1 tumors, pure teratoma, and pure yolk sac tumor, the type 2 tumors, which are biologically malignant, preceded by germ cell neoplasia in situ, and harbor chromosome 12p abnormalities, and the type 3 tumor, spermatocytic tumor, which features chromosome 9p amplification.1 These arise in distinct clinical settings, and harbor distinct genetic abnormalities, immunohistochemical properties, and morphologic features. Here we have attempted to unify embryology, morphology, immunohistochemistry, and genetics in order to distill this fascinating group of neoplasms into what we hope is a useful framework for understanding their classification.
KW - GCNIS
KW - germ cell tumor
KW - seminoma
KW - spermatocytic tumor
UR - http://www.scopus.com/inward/record.url?scp=85064189257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85064189257&partnerID=8YFLogxK
U2 - 10.1097/PAP.0000000000000233
DO - 10.1097/PAP.0000000000000233
M3 - Review article
C2 - 30950848
AN - SCOPUS:85064189257
SN - 1072-4109
VL - 26
SP - 241
EP - 245
JO - Advances in anatomic pathology
JF - Advances in anatomic pathology
IS - 4
ER -