TY - JOUR
T1 - Pathogenesis of posthemorrhagic hydrocephalus of prematurity
T2 - New horizons
AU - Robinson, Shenandoah
AU - Jantzie, Lauren L.
N1 - Funding Information:
We would like to thank the children and their families who live each day with PHHP for their strength, patience and inspiration. The authors are grateful to the Rudi Schulte Research Institute, The Hydrocephalus Association, and the Department of Defense Congressionally Directed Medical Research Program (W81XWH-18-1-0166 & W81XWH-18-1-0167) for the generous funding provided to LJ and SR for their work on hydrocephalus
Publisher Copyright:
© 2022 Elsevier Inc.
PY - 2022/8
Y1 - 2022/8
N2 - Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a vexing problem for patients, their families, and the healthcare system. The complexity of the pathogenesis of PHHP also presents a unique challenge within the fields of neonatology, neurology and neurosurgery. Here we focus on pathogenesis of PHHP and its impact on the development of CSF dynamics including choroid plexus, ependymal motile cilia and glymphatic system. PHHP is contrasted with infantile hydrocephalus from other etiologies, and with other types of posthemorrhagic hydrocephalus that occur later in life. The important concept that distinguishing ventricular volume from brain health and function is highlighted. The influence of the pathogenesis of PHHP on current interventions is reviewed, with particular emphasis on how the unique pathogenesis of PHHP contributes to the high rate of failure of current existing interventions. Finally, we discuss emerging interventions.
AB - Posthemorrhagic hydrocephalus of prematurity (PHHP) remains a vexing problem for patients, their families, and the healthcare system. The complexity of the pathogenesis of PHHP also presents a unique challenge within the fields of neonatology, neurology and neurosurgery. Here we focus on pathogenesis of PHHP and its impact on the development of CSF dynamics including choroid plexus, ependymal motile cilia and glymphatic system. PHHP is contrasted with infantile hydrocephalus from other etiologies, and with other types of posthemorrhagic hydrocephalus that occur later in life. The important concept that distinguishing ventricular volume from brain health and function is highlighted. The influence of the pathogenesis of PHHP on current interventions is reviewed, with particular emphasis on how the unique pathogenesis of PHHP contributes to the high rate of failure of current existing interventions. Finally, we discuss emerging interventions.
KW - Choroid plexus
KW - Ependymal motile cilia
KW - Glymphatic system
KW - Infantile hydrocephalus
KW - Preterm
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U2 - 10.1016/j.semperi.2022.151596
DO - 10.1016/j.semperi.2022.151596
M3 - Article
C2 - 35397898
AN - SCOPUS:85127830861
SN - 0146-0005
VL - 46
JO - Seminars in Perinatology
JF - Seminars in Perinatology
IS - 5
M1 - 151596
ER -