Pathogenesis of caprine arthritis encephalitis virus: Cellular localization of viral transcripts in tissues of infected goats

Mary Christine Zink, Julie A. Yager, Joseph D. Myers

Research output: Contribution to journalArticle

Abstract

Pathologic specimens of 18 goats with classical lesions of caprine arthritis-encephalitis (CAE) virus infection were examined morphologically and by in situ hybridization using molecularly cloned CAEV deoxyribonucleic acid (DNA) to determine which tissues and cells of naturally infected goats supported virus replication. Large numbers of cells with viral transcripts were detected in inflamed brain, spinal cord, lung, joints, and mammary gland. These cells were morphologically compatible with macrophages. Fewer cells with viral transcripts were seen in noninflamed tissues. Viral RNA was identified in macrophagelike cells in lung, liver, spleen, and lymph nodes, in cells lining the vessels of brain and synovium, and in epithelial cells of intestinal crypts, renal tubules, and thyroid follicles. These data suggest that the cell tropism of lentiviruses may extend beyond the narrow boundaries of lymphocytes and macrophages.

Original languageEnglish (US)
Pages (from-to)843-854
Number of pages12
JournalAmerican Journal of Pathology
Volume136
Issue number4
StatePublished - Apr 1990

Fingerprint

Caprine Arthritis-Encephalitis Viruses
Goats
Macrophages
Lung
Lentivirus
Tropism
Synovial Membrane
Brain
Viral RNA
Virus Diseases
Human Mammary Glands
Virus Replication
In Situ Hybridization
Spinal Cord
Thyroid Gland
Spleen
Cell Count
Joints
Lymph Nodes
Epithelial Cells

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Pathogenesis of caprine arthritis encephalitis virus : Cellular localization of viral transcripts in tissues of infected goats. / Zink, Mary Christine; Yager, Julie A.; Myers, Joseph D.

In: American Journal of Pathology, Vol. 136, No. 4, 04.1990, p. 843-854.

Research output: Contribution to journalArticle

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