TY - JOUR
T1 - Pathogenesis of Angina Pectoris
AU - Fuchs, Richard M.
AU - Becker, Lewis C.
N1 - Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1982/9
Y1 - 1982/9
N2 - There are two broad classes of angina pectoris, related to two fundamentally different pathogenetic mechanisms: in classic angina, atherosclerotic narrowings limit the ability of the coronary arteries to augment myocardial blood flow in response to increases in demand, and in variant angina, a primary reduction in coronary blood flow occurs, unrelated to changes in demand. Over the last decade, major advances have been made in our understanding of the factors that control coronary blood flow and how they interact in each of the major classes of angina. The present review examines these advances, as well as their relation to the syndromes of rest angina, postprandial angina, and exertional coronary artery spasm. Current knowledge about the mechanism by which myocardial ischemia produces the sensation of angina is discussed, along with the application of pathogenetic principles to medical therapy.
AB - There are two broad classes of angina pectoris, related to two fundamentally different pathogenetic mechanisms: in classic angina, atherosclerotic narrowings limit the ability of the coronary arteries to augment myocardial blood flow in response to increases in demand, and in variant angina, a primary reduction in coronary blood flow occurs, unrelated to changes in demand. Over the last decade, major advances have been made in our understanding of the factors that control coronary blood flow and how they interact in each of the major classes of angina. The present review examines these advances, as well as their relation to the syndromes of rest angina, postprandial angina, and exertional coronary artery spasm. Current knowledge about the mechanism by which myocardial ischemia produces the sensation of angina is discussed, along with the application of pathogenetic principles to medical therapy.
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U2 - 10.1001/archinte.1982.00340220105018
DO - 10.1001/archinte.1982.00340220105018
M3 - Article
C2 - 7052007
AN - SCOPUS:0019901035
VL - 142
SP - 1685
EP - 1692
JO - Archives of internal medicine (Chicago, Ill. : 1908)
JF - Archives of internal medicine (Chicago, Ill. : 1908)
SN - 2168-6106
IS - 9
ER -