TY - JOUR
T1 - Pathogenesis and treatment of the antiphospholipid antibody syndrome
AU - Petri, M.
PY - 1997
Y1 - 1997
N2 - Antiphospholipid antibody syndrome (APS) is one of the most important causes of thrombophilia, presenting most often as venous or arterial thrombosis, recurrent pregnancy loss, or thrombocytopenia. Both the lupus anticoagulant and anticardiolipin antibody are associated with APS. The mechanism of the prothrombotic state is not understood, but may involve beta- 2 glycoprotein I (a naturally occurring anticoagulant), platelet aggregation, the protein C pathway, or endothelial cell function. The current treatment recommendation, after a venous or arterial thrombosis, is high-intensity, long-term warfarin therapy.
AB - Antiphospholipid antibody syndrome (APS) is one of the most important causes of thrombophilia, presenting most often as venous or arterial thrombosis, recurrent pregnancy loss, or thrombocytopenia. Both the lupus anticoagulant and anticardiolipin antibody are associated with APS. The mechanism of the prothrombotic state is not understood, but may involve beta- 2 glycoprotein I (a naturally occurring anticoagulant), platelet aggregation, the protein C pathway, or endothelial cell function. The current treatment recommendation, after a venous or arterial thrombosis, is high-intensity, long-term warfarin therapy.
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U2 - 10.1016/S0025-7125(05)70509-5
DO - 10.1016/S0025-7125(05)70509-5
M3 - Article
C2 - 9012759
AN - SCOPUS:0031038480
SN - 0025-7125
VL - 81
SP - 151
EP - 177
JO - Medical Clinics of North America
JF - Medical Clinics of North America
IS - 1
ER -