Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Georgia B. Vogelsang; Linda Lee; Debra M. Bensen-Kennedy

doi:10.1146/annurev.med.54.101601.152339

Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Georgia B. Vogelsang, Linda Lee, Debra M. Bensen-Kennedy

Research output: Contribution to journal › Review article › peer-review

162 Scopus citations

Abstract

Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.

Original language	English (US)
Pages (from-to)	29-52
Number of pages	24
Journal	Annual review of medicine
Volume	54
DOIs	https://doi.org/10.1146/annurev.med.54.101601.152339
State	Published - 2003
Externally published	Yes

Keywords

Donor lymphocyte infusion
Prednisone
Sclerodermatous
Stem cell transplantation

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1146/annurev.med.54.101601.152339

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abstract = "Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.",

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AU - Lee, Linda

AU - Bensen-Kennedy, Debra M.

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AB - Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.

KW - Donor lymphocyte infusion

KW - Prednisone

KW - Sclerodermatous

KW - Stem cell transplantation

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Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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