Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Georgia B. Vogelsang, Linda Lee, Debra M. Bensen-Kennedy

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations


Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.

Original languageEnglish (US)
Pages (from-to)29-52
Number of pages24
JournalAnnual review of medicine
StatePublished - Nov 19 2003


  • Donor lymphocyte infusion
  • Prednisone
  • Sclerodermatous
  • Stem cell transplantation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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