Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Georgia B. Vogelsang; Linda Lee; Debra M. Bensen-Kennedy

doi:10.1146/annurev.med.54.101601.152339

Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant

Georgia B. Vogelsang, Linda Lee, Debra M. Bensen-Kennedy

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.

Original language	English (US)
Pages (from-to)	29-52
Number of pages	24
Journal	Annual review of medicine
Volume	54
DOIs	https://doi.org/10.1146/annurev.med.54.101601.152339
State	Published - Nov 19 2003

Keywords

Donor lymphocyte infusion
Prednisone
Sclerodermatous
Stem cell transplantation

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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