TY - JOUR
T1 - Pathogenesis and Treatment of Graft-Versus-Host Disease After Bone Marrow Transplant
AU - Vogelsang, Georgia B.
AU - Lee, Linda
AU - Bensen-Kennedy, Debra M.
PY - 2003/11/19
Y1 - 2003/11/19
N2 - Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.
AB - Stem cell transplantation is being used to treat a number of hematologic malignancies as well as hematologic and immune deficiency states. The ages of patients being offered this therapy and the donor marrow sources have been expanded. One persistent problem has been graft-versus-host disease (GVHD). This article reviews the basic biology of GVHD, clinical manifestations of acute and chronic GVHD, prophylaxis and treatment of acute GVHD, and treatment of chronic GVHD.
KW - Donor lymphocyte infusion
KW - Prednisone
KW - Sclerodermatous
KW - Stem cell transplantation
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U2 - 10.1146/annurev.med.54.101601.152339
DO - 10.1146/annurev.med.54.101601.152339
M3 - Review article
C2 - 12359826
AN - SCOPUS:0037978047
VL - 54
SP - 29
EP - 52
JO - Annual Review of Medicine
JF - Annual Review of Medicine
SN - 0066-4219
ER -