Pathogenesis and diagnosis of myocarditis

Chantal Elamm, De Lisa Fairweather, Leslie T. Cooper

Research output: Contribution to journalReview article

Abstract

Acute myocarditis is an inflammatory disease of the heart muscle that may progress to dilated cardiomyopathy and chronic heart failure. A number of factors including the sex hormone testosterone, components of innate immunity, and profibrotic cytokines have been identified in animal models as important pathogenic mechanisms that increase inflammation and susceptibility to chronic dilated cardiomyopathy. The clinical presentation of acute myocarditis is non-specific and mimics more common causes of heart failure and arrhythmias. Suspected myocarditis is currently confirmed using advanced non-invasive imaging and histopathologic examination of heart tissue. However, the diverse presentations of myocarditis and the lack of widely available, safe, and accurate non-invasive diagnostic tests remain major obstacles to early diagnosis and population based research. Recent advances in the understanding of disease pathogenesis described in this review should lead to more accurate diagnostic algorithms and non-invasive tests.

Original languageEnglish (US)
Pages (from-to)835-840
Number of pages6
JournalHeart
Volume98
Issue number11
DOIs
StatePublished - Jun 1 2012

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Pathogenesis and diagnosis of myocarditis'. Together they form a unique fingerprint.

  • Cite this

    Elamm, C., Fairweather, D. L., & Cooper, L. T. (2012). Pathogenesis and diagnosis of myocarditis. Heart, 98(11), 835-840. https://doi.org/10.1136/heartjnl-2012-301686