Pathobiology of CNS Human Immunodeficiency Virus Infection

Jennifer L. Lyons, Luis B. Tovar-y-Romo, Kiran T. Thakur, Justin C. McArthur, Norman J. Haughey

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

HIV-mediated CNS damage is a result of a combination of direct invasion of the brain by the virus and chronic immune activation leading to in situ cerebral inflammatory reactions. This can manifest clinically as chronic cognitive and/or motor impairment, and given the delicate balance of the CNS milieu, it can result in compartmentalized infection or reservoir establishment, or both. The interactions among the virus, the host immune system, and the cells of the CNS, together with effects on host metabolism, are detailed in this chapter. The implications this has on clinically overt neurological dysfunction and the effects of antiretroviral therapy are also described.

Original languageEnglish (US)
Title of host publicationNeurobiology of Brain Disorders
Subtitle of host publicationBiological Basis of Neurological and Psychiatric Disorders
PublisherElsevier Inc.
Pages444-466
Number of pages23
ISBN (Electronic)9780123982803
ISBN (Print)9780123982704
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

Keywords

  • Astrogliosis
  • CNS lipid metabolism
  • Chronic immune activation
  • Combination antiretroviral therapy
  • HIV infection
  • HIV-associated neurological disorder

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Lyons, J. L., Tovar-y-Romo, L. B., Thakur, K. T., McArthur, J. C., & Haughey, N. J. (2015). Pathobiology of CNS Human Immunodeficiency Virus Infection. In Neurobiology of Brain Disorders: Biological Basis of Neurological and Psychiatric Disorders (pp. 444-466). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-398270-4.00028-8