Path analysis of familial resemblance of pulmonary function and cigarette smoking

M. F. Cotch, Terri L Beaty, B. H. Cohen

Research output: Contribution to journalArticle

Abstract

The techniques of path analysis were utilized to assess the relative importance of genetic factors, personal smoking behavior, and shared environment in the resemblance of pulmonary function among relatives using both cross-sectional and longitudinal data from nuclear families. Data on 1-s forced expiratory volume, FEV1 (adjusted for age, sex, race, height, and ascertainment group) and the number of cigarettes smoked per day were available on 978 individuals in 384 nuclear families residing in the Baltimore metropolitan area. All these individuals were seen twice between 1971 and 1981, with an average of 5 yr between visits. The direct effect of an individual's own smoking explained 10 and 3% of variation in adjusted FEV1 among parents and offspring, respectively. Shared environmental factors influencing personal smoking behavior accounted for 5% of the parent-offspring correlation in adjusted FEV1 and 3% of the sibling correlation in adjusted FEV1 in this sample. Undefined environmental factors that influenced an individual's smoking habits and could be shared among relatives were found to explain 19% of the familial correlations in smoking. Genetic heritability estimates ranged between 36 and 40%, with no evidence of intergenerational differences in the expression of apparent genetic control of pulmonary function.

Original languageEnglish (US)
Pages (from-to)1337-1343
Number of pages7
JournalAmerican Review of Respiratory Disease
Volume142
Issue number6
StatePublished - 1990

Fingerprint

Smoking
Lung
Nuclear Family
Baltimore
Forced Expiratory Volume
Tobacco Products
Habits
Siblings
Parents

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Path analysis of familial resemblance of pulmonary function and cigarette smoking. / Cotch, M. F.; Beaty, Terri L; Cohen, B. H.

In: American Review of Respiratory Disease, Vol. 142, No. 6, 1990, p. 1337-1343.

Research output: Contribution to journalArticle

@article{af4a08d01f014330919296789a1d571e,
title = "Path analysis of familial resemblance of pulmonary function and cigarette smoking",
abstract = "The techniques of path analysis were utilized to assess the relative importance of genetic factors, personal smoking behavior, and shared environment in the resemblance of pulmonary function among relatives using both cross-sectional and longitudinal data from nuclear families. Data on 1-s forced expiratory volume, FEV1 (adjusted for age, sex, race, height, and ascertainment group) and the number of cigarettes smoked per day were available on 978 individuals in 384 nuclear families residing in the Baltimore metropolitan area. All these individuals were seen twice between 1971 and 1981, with an average of 5 yr between visits. The direct effect of an individual's own smoking explained 10 and 3{\%} of variation in adjusted FEV1 among parents and offspring, respectively. Shared environmental factors influencing personal smoking behavior accounted for 5{\%} of the parent-offspring correlation in adjusted FEV1 and 3{\%} of the sibling correlation in adjusted FEV1 in this sample. Undefined environmental factors that influenced an individual's smoking habits and could be shared among relatives were found to explain 19{\%} of the familial correlations in smoking. Genetic heritability estimates ranged between 36 and 40{\%}, with no evidence of intergenerational differences in the expression of apparent genetic control of pulmonary function.",
author = "Cotch, {M. F.} and Beaty, {Terri L} and Cohen, {B. H.}",
year = "1990",
language = "English (US)",
volume = "142",
pages = "1337--1343",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "6",

}

TY - JOUR

T1 - Path analysis of familial resemblance of pulmonary function and cigarette smoking

AU - Cotch, M. F.

AU - Beaty, Terri L

AU - Cohen, B. H.

PY - 1990

Y1 - 1990

N2 - The techniques of path analysis were utilized to assess the relative importance of genetic factors, personal smoking behavior, and shared environment in the resemblance of pulmonary function among relatives using both cross-sectional and longitudinal data from nuclear families. Data on 1-s forced expiratory volume, FEV1 (adjusted for age, sex, race, height, and ascertainment group) and the number of cigarettes smoked per day were available on 978 individuals in 384 nuclear families residing in the Baltimore metropolitan area. All these individuals were seen twice between 1971 and 1981, with an average of 5 yr between visits. The direct effect of an individual's own smoking explained 10 and 3% of variation in adjusted FEV1 among parents and offspring, respectively. Shared environmental factors influencing personal smoking behavior accounted for 5% of the parent-offspring correlation in adjusted FEV1 and 3% of the sibling correlation in adjusted FEV1 in this sample. Undefined environmental factors that influenced an individual's smoking habits and could be shared among relatives were found to explain 19% of the familial correlations in smoking. Genetic heritability estimates ranged between 36 and 40%, with no evidence of intergenerational differences in the expression of apparent genetic control of pulmonary function.

AB - The techniques of path analysis were utilized to assess the relative importance of genetic factors, personal smoking behavior, and shared environment in the resemblance of pulmonary function among relatives using both cross-sectional and longitudinal data from nuclear families. Data on 1-s forced expiratory volume, FEV1 (adjusted for age, sex, race, height, and ascertainment group) and the number of cigarettes smoked per day were available on 978 individuals in 384 nuclear families residing in the Baltimore metropolitan area. All these individuals were seen twice between 1971 and 1981, with an average of 5 yr between visits. The direct effect of an individual's own smoking explained 10 and 3% of variation in adjusted FEV1 among parents and offspring, respectively. Shared environmental factors influencing personal smoking behavior accounted for 5% of the parent-offspring correlation in adjusted FEV1 and 3% of the sibling correlation in adjusted FEV1 in this sample. Undefined environmental factors that influenced an individual's smoking habits and could be shared among relatives were found to explain 19% of the familial correlations in smoking. Genetic heritability estimates ranged between 36 and 40%, with no evidence of intergenerational differences in the expression of apparent genetic control of pulmonary function.

UR - http://www.scopus.com/inward/record.url?scp=0025609658&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025609658&partnerID=8YFLogxK

M3 - Article

C2 - 2252251

AN - SCOPUS:0025609658

VL - 142

SP - 1337

EP - 1343

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 6

ER -