Abstract
Patent ductus arteriosus (PDA) has been found in several members in consecutive generations of two families. In one family the proband's father had affected children through two matings with unrelated wives. In both families, operation confirmed the PDA in each case in two generations. However, in the second family, a maternal great aunt of the proband had characteristic clinical findings, thus making three generations affected. This sequence is best explained by autosomal dominant inheritance with a high degree of specificity. Two other mechanisms for production of PDA seem well established by other studies: (1) maternal rubella and (2) a recessive characteristic. Further family studies are needed to clarify the exact mode of inheritance.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-138 |
| Number of pages | 4 |
| Journal | Journal of the American Medical Association |
| Volume | 194 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 11 1965 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
Cite this
Patent Ductus Arteriosus : Study of two Families. / Lynch, H. T.; Grissom, R. L.; Magnuson, C. R.; Krush, A.
In: Journal of the American Medical Association, Vol. 194, No. 2, 11.10.1965, p. 135-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Patent Ductus Arteriosus
T2 - Study of two Families
AU - Lynch, H. T.
AU - Grissom, R. L.
AU - Magnuson, C. R.
AU - Krush, A.
PY - 1965/10/11
Y1 - 1965/10/11
N2 - Patent ductus arteriosus (PDA) has been found in several members in consecutive generations of two families. In one family the proband's father had affected children through two matings with unrelated wives. In both families, operation confirmed the PDA in each case in two generations. However, in the second family, a maternal great aunt of the proband had characteristic clinical findings, thus making three generations affected. This sequence is best explained by autosomal dominant inheritance with a high degree of specificity. Two other mechanisms for production of PDA seem well established by other studies: (1) maternal rubella and (2) a recessive characteristic. Further family studies are needed to clarify the exact mode of inheritance.
AB - Patent ductus arteriosus (PDA) has been found in several members in consecutive generations of two families. In one family the proband's father had affected children through two matings with unrelated wives. In both families, operation confirmed the PDA in each case in two generations. However, in the second family, a maternal great aunt of the proband had characteristic clinical findings, thus making three generations affected. This sequence is best explained by autosomal dominant inheritance with a high degree of specificity. Two other mechanisms for production of PDA seem well established by other studies: (1) maternal rubella and (2) a recessive characteristic. Further family studies are needed to clarify the exact mode of inheritance.
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UR - http://www.scopus.com/inward/citedby.url?scp=0005893033&partnerID=8YFLogxK
U2 - 10.1001/jama.1965.03090150027007
DO - 10.1001/jama.1965.03090150027007
M3 - Article
C2 - 5897316
AN - SCOPUS:0005893033
VL - 194
SP - 135
EP - 138
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
SN - 0098-7484
IS - 2
ER -