Past adult lead exposure is linked to neurodegeneration measured by brain MRI

W. F. Stewart, Brian S Schwartz, C. Davatzikos, D. Shen, D. Liu, X. Wu, A. C. Todd, W. Shi, Susan Bassett, David Mark Yousem

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To determine whether cumulative lead dose in former organolead workers was associated with MRI measures of white matter lesions (WML) and global and structure-specific brain volumes. METHODS: MRIs, tibia lead, and other measures were obtained from 532 former organolead workers with a mean age of 56 years and a mean of 18 years since last occupational exposure to lead. Cumulative lead dose was measured by tibia lead, obtained by X-ray fluorescence, and expressed as μg lead per gram of bone mineral (μg Pb/g). WML were evaluated using the Cardiovascular Health Study grading scale. A total of 21 global and specific brain regions were evaluated. RESULTS: A total of 36% of individuals had WML grade of 1 to 7 (0 to 9 scale). Increasing peak tibia lead was associated with increasing WML grade (p = 0.004). The adjusted OR for a 1 μg Pb/g increase in tibia lead was 1.042 (95% CI = 1.021, 1.063) for a CHS grade of 5+ (≥5 vs

Original languageEnglish (US)
Pages (from-to)1476-1484
Number of pages9
JournalNeurology
Volume66
Issue number10
DOIs
StatePublished - May 2006

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Tibia
Brain
Occupational Exposure
Minerals
Lead
Fluorescence
X-Rays
Bone and Bones
White Matter
Health

ASJC Scopus subject areas

  • Neuroscience(all)

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Past adult lead exposure is linked to neurodegeneration measured by brain MRI. / Stewart, W. F.; Schwartz, Brian S; Davatzikos, C.; Shen, D.; Liu, D.; Wu, X.; Todd, A. C.; Shi, W.; Bassett, Susan; Yousem, David Mark.

In: Neurology, Vol. 66, No. 10, 05.2006, p. 1476-1484.

Research output: Contribution to journalArticle

Stewart, W. F. ; Schwartz, Brian S ; Davatzikos, C. ; Shen, D. ; Liu, D. ; Wu, X. ; Todd, A. C. ; Shi, W. ; Bassett, Susan ; Yousem, David Mark. / Past adult lead exposure is linked to neurodegeneration measured by brain MRI. In: Neurology. 2006 ; Vol. 66, No. 10. pp. 1476-1484.
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AU - Schwartz, Brian S

AU - Davatzikos, C.

AU - Shen, D.

AU - Liu, D.

AU - Wu, X.

AU - Todd, A. C.

AU - Shi, W.

AU - Bassett, Susan

AU - Yousem, David Mark

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