Passive transfer of arthritis by purified anticollagen immunoglobulin: Localization of 125I-labeled antibody

S. S. Kerwar; Samuel Gordon; Richard A. McReynolds; Arnold L. Oronsky

doi:10.1016/0090-1229(83)90033-8

Passive transfer of arthritis by purified anticollagen immunoglobulin: Localization of ¹²⁵I-labeled antibody

S. S. Kerwar, Samuel Gordon, Richard A. McReynolds, Arnold L. Oronsky

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Intravenous administration of purified ¹²⁵I-labeled anti-type II collagen immunoglobulin results in a polyarthritis in the recipient rats. Whole-animal radioautography indicates that the antibody is present in the various tissues that contain Type II collagen. However, the polyarthritic lesion is limited to the front and hind paws. These observations indicate that effector mechanisms subsequent to antibody binding are involved in the pathogenesis of Type II collagen-induced arthritis.

Original language	English (US)
Pages (from-to)	318-321
Number of pages	4
Journal	Clinical Immunology and Immunopathology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(83)90033-8
State	Published - Nov 1983

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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abstract = "Intravenous administration of purified 125I-labeled anti-type II collagen immunoglobulin results in a polyarthritis in the recipient rats. Whole-animal radioautography indicates that the antibody is present in the various tissues that contain Type II collagen. However, the polyarthritic lesion is limited to the front and hind paws. These observations indicate that effector mechanisms subsequent to antibody binding are involved in the pathogenesis of Type II collagen-induced arthritis.",

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