TY - JOUR
T1 - Passive transfer of arthritis by purified anticollagen immunoglobulin
T2 - Localization of 125I-labeled antibody
AU - Kerwar, S. S.
AU - Gordon, Samuel
AU - McReynolds, Richard A.
AU - Oronsky, Arnold L.
PY - 1983/11
Y1 - 1983/11
N2 - Intravenous administration of purified 125I-labeled anti-type II collagen immunoglobulin results in a polyarthritis in the recipient rats. Whole-animal radioautography indicates that the antibody is present in the various tissues that contain Type II collagen. However, the polyarthritic lesion is limited to the front and hind paws. These observations indicate that effector mechanisms subsequent to antibody binding are involved in the pathogenesis of Type II collagen-induced arthritis.
AB - Intravenous administration of purified 125I-labeled anti-type II collagen immunoglobulin results in a polyarthritis in the recipient rats. Whole-animal radioautography indicates that the antibody is present in the various tissues that contain Type II collagen. However, the polyarthritic lesion is limited to the front and hind paws. These observations indicate that effector mechanisms subsequent to antibody binding are involved in the pathogenesis of Type II collagen-induced arthritis.
UR - http://www.scopus.com/inward/record.url?scp=0020516049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0020516049&partnerID=8YFLogxK
U2 - 10.1016/0090-1229(83)90033-8
DO - 10.1016/0090-1229(83)90033-8
M3 - Article
C2 - 6627761
AN - SCOPUS:0020516049
SN - 0090-1229
VL - 29
SP - 318
EP - 321
JO - Clinical Immunology and Immunopathology
JF - Clinical Immunology and Immunopathology
IS - 2
ER -