Intravenous administration of purified 125I-labeled anti-type II collagen immunoglobulin results in a polyarthritis in the recipient rats. Whole-animal radioautography indicates that the antibody is present in the various tissues that contain Type II collagen. However, the polyarthritic lesion is limited to the front and hind paws. These observations indicate that effector mechanisms subsequent to antibody binding are involved in the pathogenesis of Type II collagen-induced arthritis.
ASJC Scopus subject areas
- Immunology and Allergy
- Pathology and Forensic Medicine