Abstract
Possible functional heterogeneity of human IgE antibody was studied by passively sensitizing human basophils for antigen-induced histamine release. Six sera of known IgE anti-ragweed antigen E and total IgE content were diluted to contain 10 ng of antibody but differed with respect to the ratio of specific/total IgE. The relative ability of the sera to passively sensitize generally reflected the specific/total IgE ratio but one serum was 2.5 times more active than the remainder. This ability did not reflect the IgG antibody level nor was it due to a dialyzable or heat-stable factor. These data indicate functional IgE heterogeneity, probably due to the interaction of the Fc portion of IgE with the basophil receptor.
Original language | English (US) |
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Pages (from-to) | 106-109 |
Number of pages | 4 |
Journal | International archives of allergy and immunology |
Volume | 60 |
Issue number | 1 |
DOIs | |
State | Published - 1979 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology