@article{f6d322852980453db4b1d654a7098dd4,
title = "Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus",
abstract = "Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin- expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.",
author = "Juan Song and Jiaqi Sun and Jonathan Moss and Zhexing Wen and Sun, {Gerald J.} and Derek Hsu and Chun Zhong and Heydar Davoudi and Christian, {Kimberly M.} and Nicolas Toni and Ming, {Guo Li} and Hongjun Song",
note = "Funding Information: We thank members of the Song and Ming laboratories for discussion, L. Tsai and K. Deisseroth for initial help with optogenetics, and Q. Hussaini, Y. Cai and L. Liu for technical support. The electron microscopy images were acquired at the electron microscopy facility of the University of Lausanne. This work was supported by grants from the US National Institutes of Health (NS047344, ES021957) and The Brain & Behavior Research Foundation to H.S., from the US National Institutes of Health (NS048271, HD069184), the Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, The Brain & Behavior Research Foundation and Maryland Stem Cell Research Fund to G.M., from the Swiss National Science Foundation (PP00A-119026/1) to N.T., from The Brain & Behavior Research Foundationand Maryland Stem Cell Research Fund to K.M.C., by postdoctoral fellowships from Maryland Stem Cell Research Fund to J. Song, Z.W. and C.Z., from the Fondation Leenaards to J.M., and by a pre-doctoral fellowship from The Children{\textquoteright}s Tumor Foundation to G.J.S.",
year = "2013",
doi = "10.1038/nn.3572",
language = "English (US)",
volume = "16",
pages = "1728--1730",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "12",
}