Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus

Juan Song, Jiaqi Sun, Jonathan Moss, Zhexing Wen, Gerald J. Sun, Derek Hsu, Chun Zhong, Heydar Davoudi, Kimberly M. Christian, Nicolas Toni, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticle

Abstract

Using immunohistology, electron microscopy, electrophysiology and optogenetics, we found that proliferating adult mouse hippocampal neural precursors received immature GABAergic synaptic inputs from parvalbumin- expressing interneurons. Recently shown to suppress adult quiescent neural stem cell activation, parvalbumin interneuron activation promoted newborn neuronal progeny survival and development. Our results suggest a niche mechanism involving parvalbumin interneurons that couples local circuit activity to the diametric regulation of two critical early phases of adult hippocampal neurogenesis.

Original languageEnglish (US)
Pages (from-to)1728-1730
Number of pages3
JournalNature neuroscience
Volume16
Issue number12
DOIs
StatePublished - Nov 11 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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    Song, J., Sun, J., Moss, J., Wen, Z., Sun, G. J., Hsu, D., Zhong, C., Davoudi, H., Christian, K. M., Toni, N., Ming, G. L., & Song, H. (2013). Parvalbumin interneurons mediate neuronal circuitry-neurogenesis coupling in the adult hippocampus. Nature neuroscience, 16(12), 1728-1730. https://doi.org/10.1038/nn.3572