Partners in Crime: Phenolic Glycolipids and Macrophages

Alok Kumar Singh, William R. Bishai

Research output: Contribution to journalShort surveypeer-review

Abstract

Two recent articles advance our understanding of mycobacterial pathogenesis, revealing key roles for bacterially derived phenolic glycolipids (PGLs). In leprosy, Mycobacterium leprae PGL-1 uniquely subverts local macrophages to produce neurotoxic nitric oxide (NO), leading to nerve demyelination. In a related model, Mycobacterium marinum PGL stimulates the recruitment of growth-conducive monocytes to sites of initial infection as an early immune evasion strategy.

Original languageEnglish (US)
Pages (from-to)981-983
Number of pages3
JournalTrends in Molecular Medicine
Volume23
Issue number11
DOIs
StatePublished - Nov 2017

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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