Partner Human Papillomavirus Viral Load and Incident Human Papillomavirus Detection in Heterosexual Couples

Mary K. Grabowski, Xiangrong Kong, Ronald H. Gray, David Serwadda, Godfrey Kigozi, Patti E. Gravitt, Fred Nalugoda, Steven J. Reynolds, Maria J. Wawer, Andrew D. Redd, Stephen Watya, Thomas C. Quinn, Aaron A.R. Tobian

Research output: Contribution to journalArticlepeer-review

Abstract

Background. The association between partner human papillomavirus (HPV) viral load and incident HPV detection in heterosexual couples is unknown. Methods. HPV genotypes were detected in 632 human immunodeficiency virus (HIV)-negative couples followed for 2 years in a male circumcision trial in Rakai, Uganda, using the Roche HPV Linear Array. This assay detects 37 genotypes and provides a semiquantitative measure of viral load based on the intensity (graded 1-4) of the genotype-specific band; a band intensity of 1 indicates a low genotype-specific HPV load, whereas an intensity of 4 indicates a high load. Using Poisson regression with generalized estimating equations, we measured the association between partner's genotype-specific viral load and detection of that genotype in the HPV-discordant partner 1 year later. Results. Incident detection of HPV genotypes was 10.6% among men (54 of 508 genotype-specific visit intervals) and 9.0% among women (55 of 611 genotype-specific visit intervals). Use of male partners with a baseline genotype-specific band intensity of 1 as a reference yielded adjusted relative risks (aRRs) of 1.14 (95% confidence interval [CI],. 58-2.27]) for incident detection of that genotype among women whose male partner had a baseline band intensity of 2, 1.75 (95% CI,. 97-3.17) among those whose partner had an intensity of 3, and 2.52 (95% CI, 1.40-4.54) among those whose partner had an intensity of 4. Use of female partners with a baseline genotype-specific band intensity of 1 as a reference yielded an aRR of 2.83 (95% CI, 1.50-5.33) for incident detection of that genotype among men whose female partner had a baseline band intensity of 4. These associations were similar for high-risk and low-risk genotypes. Male circumcision also was associated with significant reductions in incident HPV detection in men (aRR, 0.53 [95% CI,. 30-.95]) and women (aRR, 0.42 [95% CI,. 23-.76]). Conclusions. In heterosexual couples, the genotype-specific HPV load in one partner is associated with the risk of new detection of that genotype in the other partner. Interventions that reduce the HPV load may reduce the incidence of HPV transmission.

Original languageEnglish (US)
Pages (from-to)948-956
Number of pages9
JournalJournal of Infectious Diseases
Volume213
Issue number6
DOIs
StatePublished - Mar 15 2016

Keywords

  • Africa
  • HIV
  • Uganda
  • cervical cancer
  • human papillomavirus
  • male circumcision
  • penile cancer
  • sexually transmitted infections
  • transmission
  • viral load

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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