Partition coefficients for gadolinium chelates in the normal myocardium

Comparison of gadopentetate dimeglumine and gadobenate dimeglumine

Nadine Kawel, Marcelo Nacif, Francesco Santini, Songtao Liu, Jens Bremerich, Andrew E. Arai, David A. Bluemke

Research output: Contribution to journalArticle

Abstract

Purpose: To evaluate the influence of contrast agents with different relaxivity on the partition coefficient (λ) and timing of equilibration using a modified Look-Locker inversion recovery (MOLLI) sequence in cardiac magnetic resonance imaging (MRI). Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at the mid-ventricular short axis precontrast and 5, 10, 20, 25, and 30 minutes after administration of a bolus of 0.15 mmol/kg gadobenate dimeglumine (Gd-BOPTA) (n = 10) or gadopentetate dimeglumine (Gd-DTPA) (n = 10). T1 times were measured in myocardium and blood pool. λ was approximated by δR1myocardium/δR1 blood. Values for Gd-BOPTA and Gd-DTPA were compared. Interobserver agreement was evaluated (intraclass correlation coefficient [ICC]). Results: T1 times of myocardium and blood pool (P <0.001) and λ (0.42 ± 0.03 and 0.47 ± 0.04, respectively, P <0.001; excluding 5 minutes for Gd-BOPTA) were significantly lower for Gd-BOPTA than Gd-DTPA. The λ(Gd-DTPA) showed no significant variation between 5 and 30 minutes. The λ(Gd-BOPTA) values were significantly lower at 5 minutes compared to other times (0.38 vs. 0.42; P <0.05). Interobserver agreement for λ values was excellent with Gd-BOPTA (ICC = 0.818) and good for Gd-DTPA (ICC = 0.631). Conclusion: The λ(Gd-BOPTA) values were significantly lower compared to λ(Gd-DTPA) at the same administered dose. Using Gd-BOPTA, the equilibrium between myocardium and blood pool was not achieved at 5 minutes postcontrast. J. Magn. Reson. Imaging 2012;36:733-737.

Original languageEnglish (US)
Pages (from-to)733-737
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Volume36
Issue number3
DOIs
StatePublished - Sep 2012
Externally publishedYes

Fingerprint

Gadolinium DTPA
Gadolinium
Myocardium
Sequence Inversion
gadobenic acid
Contrast Media
Healthy Volunteers
Magnetic Resonance Imaging

Keywords

  • gadobenate dimeglumine
  • gadopentetate dimeglumine
  • modified Look-Locker inversion recovery, partition coefficient
  • T1 mapping

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Partition coefficients for gadolinium chelates in the normal myocardium : Comparison of gadopentetate dimeglumine and gadobenate dimeglumine. / Kawel, Nadine; Nacif, Marcelo; Santini, Francesco; Liu, Songtao; Bremerich, Jens; Arai, Andrew E.; Bluemke, David A.

In: Journal of Magnetic Resonance Imaging, Vol. 36, No. 3, 09.2012, p. 733-737.

Research output: Contribution to journalArticle

Kawel, Nadine ; Nacif, Marcelo ; Santini, Francesco ; Liu, Songtao ; Bremerich, Jens ; Arai, Andrew E. ; Bluemke, David A. / Partition coefficients for gadolinium chelates in the normal myocardium : Comparison of gadopentetate dimeglumine and gadobenate dimeglumine. In: Journal of Magnetic Resonance Imaging. 2012 ; Vol. 36, No. 3. pp. 733-737.
@article{2562fa95311d4a9186c979e92d2a52e8,
title = "Partition coefficients for gadolinium chelates in the normal myocardium: Comparison of gadopentetate dimeglumine and gadobenate dimeglumine",
abstract = "Purpose: To evaluate the influence of contrast agents with different relaxivity on the partition coefficient (λ) and timing of equilibration using a modified Look-Locker inversion recovery (MOLLI) sequence in cardiac magnetic resonance imaging (MRI). Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at the mid-ventricular short axis precontrast and 5, 10, 20, 25, and 30 minutes after administration of a bolus of 0.15 mmol/kg gadobenate dimeglumine (Gd-BOPTA) (n = 10) or gadopentetate dimeglumine (Gd-DTPA) (n = 10). T1 times were measured in myocardium and blood pool. λ was approximated by δR1myocardium/δR1 blood. Values for Gd-BOPTA and Gd-DTPA were compared. Interobserver agreement was evaluated (intraclass correlation coefficient [ICC]). Results: T1 times of myocardium and blood pool (P <0.001) and λ (0.42 ± 0.03 and 0.47 ± 0.04, respectively, P <0.001; excluding 5 minutes for Gd-BOPTA) were significantly lower for Gd-BOPTA than Gd-DTPA. The λ(Gd-DTPA) showed no significant variation between 5 and 30 minutes. The λ(Gd-BOPTA) values were significantly lower at 5 minutes compared to other times (0.38 vs. 0.42; P <0.05). Interobserver agreement for λ values was excellent with Gd-BOPTA (ICC = 0.818) and good for Gd-DTPA (ICC = 0.631). Conclusion: The λ(Gd-BOPTA) values were significantly lower compared to λ(Gd-DTPA) at the same administered dose. Using Gd-BOPTA, the equilibrium between myocardium and blood pool was not achieved at 5 minutes postcontrast. J. Magn. Reson. Imaging 2012;36:733-737.",
keywords = "gadobenate dimeglumine, gadopentetate dimeglumine, modified Look-Locker inversion recovery, partition coefficient, T1 mapping",
author = "Nadine Kawel and Marcelo Nacif and Francesco Santini and Songtao Liu and Jens Bremerich and Arai, {Andrew E.} and Bluemke, {David A.}",
year = "2012",
month = "9",
doi = "10.1002/jmri.23651",
language = "English (US)",
volume = "36",
pages = "733--737",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

TY - JOUR

T1 - Partition coefficients for gadolinium chelates in the normal myocardium

T2 - Comparison of gadopentetate dimeglumine and gadobenate dimeglumine

AU - Kawel, Nadine

AU - Nacif, Marcelo

AU - Santini, Francesco

AU - Liu, Songtao

AU - Bremerich, Jens

AU - Arai, Andrew E.

AU - Bluemke, David A.

PY - 2012/9

Y1 - 2012/9

N2 - Purpose: To evaluate the influence of contrast agents with different relaxivity on the partition coefficient (λ) and timing of equilibration using a modified Look-Locker inversion recovery (MOLLI) sequence in cardiac magnetic resonance imaging (MRI). Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at the mid-ventricular short axis precontrast and 5, 10, 20, 25, and 30 minutes after administration of a bolus of 0.15 mmol/kg gadobenate dimeglumine (Gd-BOPTA) (n = 10) or gadopentetate dimeglumine (Gd-DTPA) (n = 10). T1 times were measured in myocardium and blood pool. λ was approximated by δR1myocardium/δR1 blood. Values for Gd-BOPTA and Gd-DTPA were compared. Interobserver agreement was evaluated (intraclass correlation coefficient [ICC]). Results: T1 times of myocardium and blood pool (P <0.001) and λ (0.42 ± 0.03 and 0.47 ± 0.04, respectively, P <0.001; excluding 5 minutes for Gd-BOPTA) were significantly lower for Gd-BOPTA than Gd-DTPA. The λ(Gd-DTPA) showed no significant variation between 5 and 30 minutes. The λ(Gd-BOPTA) values were significantly lower at 5 minutes compared to other times (0.38 vs. 0.42; P <0.05). Interobserver agreement for λ values was excellent with Gd-BOPTA (ICC = 0.818) and good for Gd-DTPA (ICC = 0.631). Conclusion: The λ(Gd-BOPTA) values were significantly lower compared to λ(Gd-DTPA) at the same administered dose. Using Gd-BOPTA, the equilibrium between myocardium and blood pool was not achieved at 5 minutes postcontrast. J. Magn. Reson. Imaging 2012;36:733-737.

AB - Purpose: To evaluate the influence of contrast agents with different relaxivity on the partition coefficient (λ) and timing of equilibration using a modified Look-Locker inversion recovery (MOLLI) sequence in cardiac magnetic resonance imaging (MRI). Materials and Methods: MOLLI was acquired in 20 healthy subjects (1.5T) at the mid-ventricular short axis precontrast and 5, 10, 20, 25, and 30 minutes after administration of a bolus of 0.15 mmol/kg gadobenate dimeglumine (Gd-BOPTA) (n = 10) or gadopentetate dimeglumine (Gd-DTPA) (n = 10). T1 times were measured in myocardium and blood pool. λ was approximated by δR1myocardium/δR1 blood. Values for Gd-BOPTA and Gd-DTPA were compared. Interobserver agreement was evaluated (intraclass correlation coefficient [ICC]). Results: T1 times of myocardium and blood pool (P <0.001) and λ (0.42 ± 0.03 and 0.47 ± 0.04, respectively, P <0.001; excluding 5 minutes for Gd-BOPTA) were significantly lower for Gd-BOPTA than Gd-DTPA. The λ(Gd-DTPA) showed no significant variation between 5 and 30 minutes. The λ(Gd-BOPTA) values were significantly lower at 5 minutes compared to other times (0.38 vs. 0.42; P <0.05). Interobserver agreement for λ values was excellent with Gd-BOPTA (ICC = 0.818) and good for Gd-DTPA (ICC = 0.631). Conclusion: The λ(Gd-BOPTA) values were significantly lower compared to λ(Gd-DTPA) at the same administered dose. Using Gd-BOPTA, the equilibrium between myocardium and blood pool was not achieved at 5 minutes postcontrast. J. Magn. Reson. Imaging 2012;36:733-737.

KW - gadobenate dimeglumine

KW - gadopentetate dimeglumine

KW - modified Look-Locker inversion recovery, partition coefficient

KW - T1 mapping

UR - http://www.scopus.com/inward/record.url?scp=84865311488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865311488&partnerID=8YFLogxK

U2 - 10.1002/jmri.23651

DO - 10.1002/jmri.23651

M3 - Article

VL - 36

SP - 733

EP - 737

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 3

ER -