Particulate bioglass stimulate IL-1α and the TNFα secretion in human synoviocytes

S. P. Bendall, M. G. Gaies, C. Frondoza, R. H. Jinnah, D. S. Hungerford

Research output: Contribution to conferencePaperpeer-review

Abstract

One of the disadvantages of using bioglass as an implant coating material is that it is a highly resorbable ceramic that can fragment into particulate debris in vivo and stimulate inflammatory and osteolytic response. An experiment was conducted to determine whether particulate bioactive glass elicits an inflammatory response using human synoviocytes as target tissue cells. Synoviocytes were isolated from synovial tissue of a rheumatoid arthritic patient undergoing joint replacement surgery. Particulate bioglass was found to have minimal inhibitory effect on the proliferation of human synoviocytes. However, bioglass was found to induce an inflammatory response as shown by the release of cytokines TNFα and Il-1α.

Original languageEnglish (US)
Number of pages1
StatePublished - Dec 1 1996
EventProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2) - Toronto, Can
Duration: May 29 1996Jun 2 1996

Other

OtherProceedings of the 1996 5th World Biomaterials Congress. Part 2 (of 2)
CityToronto, Can
Period5/29/966/2/96

ASJC Scopus subject areas

  • Materials Science(all)

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