Participation of cyclin A in Myc-induced apoptosis

Arthur T. Hoang, Kenneth J. Cohen, John F. Barrett, Donald A. Bergstrom, Chi V. Dang

Research output: Contribution to journalArticle

Abstract

The involvement of c-Myc in cellular proliferation or apoptosis has been linked to differential cyclin gene expression. We observed that in both proliferating cells and cells undergoing apoptosis, cyclin A (but not B, C, D1, and E) mRNA level was elevated in unsynchronized Myc-overexpressing cells when compared with parental Rat1a fibroblasts. We further demonstrated that Zn2+-inducible cyclin A expression was sufficient to cause apoptosis. When Myc-induced apoptosis was blocked by coexpression of Bcl-2, the levels of cyclin C, D1, and E mRNAs were also elevated. Thus, while apoptosis induced by c-Myc is associated with an elevated cyclin A mRNA level, protection from apoptosis by coexpressed Bcl-2 is associated with a complementary increase in cyclin C, D1, and E mRNAs.

Original languageEnglish (US)
Pages (from-to)6875-6879
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume91
Issue number15
DOIs
StatePublished - Jul 19 1994

Keywords

  • cell cycle
  • oncogene
  • programmed cell death

ASJC Scopus subject areas

  • General

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