Partial Volume Effect of thickness, inner diameter and positron range in small animal cardiac PET imaging

M. J. Park, G. S.K. Fung, T. Yamane, F. Kaiser, K. Fukushima, T. Higuchi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Partial Volume Effect (PVE), the image blurring caused by the finite spatial resolution of PET imaging system, can cause incorrect quantification of radioactivity especially for small objects. High-resolution small animal PET system has been developed for rodents, but sizes of rodent hearts are still close to the spatial resolution, that might cause significant PVE than human heart in clinic PET. The aim is to evaluate PVE of various heart-shaped phantoms in a small animal PET system utilizing Monte Carlo (MC) simulation. We built a simulation platform using a MC simulation (SimSET+GATE) and reconstruction software (STIR) based on the scanner configuration of a small animal PET system (Inveon). To confirm the spatial resolution, a line source in a water-filled cylinder was measured and simulated at the center of field of view. Simplified model of heart, combinations of thickness (0.5-18mm) and inner diameter (1-10mm) of hollow-cylindrical source, were simulated with F-18 and Ga-68. Sinograms of true events were rebinned by FORE and reconstructed by 2D OS-EM (32 updates) with attenuation correction and Gaussian post-filtering (1.4mm FWHM). Recovery coefficients (RCs) were estimated by average over 50% of maximum value using a big cylindrical source (40mm diameter) as the reference. RC at the specific size was estimated by bilinear interpolation. Averaged FWHMs on the sinogram for F-18 and Ga-68 were about 1.7 and 3.9mm in MC simulation and 1.8 and 3.7mm in real measurement, respectively. RCs were 30.4% and 21.2% for F-18 and 20.5% and 14.5% for Ga-68 at the end of diastolic phase (ED) of the left ventricle (LV) of a rat and a mouse heart size (measured on MRI; 8 and 1 mm, 4 and 0.65mm for inner diameter and wall thickness, respectively). We developed a MC simulation platform and observed considerable count reductions (70-85%) by PVE in rodent heart size with small animal PET. This platform has the further potential use for developing new PVE compensation algorithms.

Original languageEnglish (US)
Title of host publication2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Print)9781479905348
DOIs
StatePublished - Jan 1 2013
Event2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of
Duration: Oct 27 2013Nov 2 2013

Publication series

NameIEEE Nuclear Science Symposium Conference Record
ISSN (Print)1095-7863

Other

Other2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
CountryKorea, Republic of
CitySeoul
Period10/27/1311/2/13

ASJC Scopus subject areas

  • Radiation
  • Nuclear and High Energy Physics
  • Radiology Nuclear Medicine and imaging

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    Park, M. J., Fung, G. S. K., Yamane, T., Kaiser, F., Fukushima, K., & Higuchi, T. (2013). Partial Volume Effect of thickness, inner diameter and positron range in small animal cardiac PET imaging. In 2013 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 [6829109] (IEEE Nuclear Science Symposium Conference Record). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829109