Partial structure and mapping of the human myelin P2 protein gene

Vinodh Narayanan, Benedetta Ripepi, Ethylin Wang Jabs, Anita Hawkins, Constance Griffin, Gihan Tennekoon

Research output: Contribution to journalArticle

Abstract

The myelin P2 protein, a 14,800-Da cytosolic protein found primarily in peripheral nerves, belongs to a family of fatty acid binding proteins. Although it is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. It is detected only in myelin- producing cells of the central and peripheral nervous systems, i.e., the oligodendrocytes and Schwann cells, respectively. As part of a program to understand the regulation of expression of this gene, to determine its function in myelin-producing cells, and to study its role in peripheral nerve disease, we have isolated and characterized overlapping human genomic clones encoding the P2 protein. We report here on the partial structure of this gene, and on its localization within the genome. By using a panel of human- hamster somatic cell hybrids and by in situ hybridization, we have mapped the human P2 gene to segment q21 on the long arm of chromosome 8. This result identifies the myelin P2 gene as a candidate gene for autosomal recessive Charcot-Marie-Tooth disease type 4A.

Original languageEnglish (US)
Pages (from-to)2010-2013
Number of pages4
JournalJournal of Neurochemistry
Volume63
Issue number6
StatePublished - Dec 1994

Keywords

  • Chromosomal mapping
  • Human P gene
  • Myelin
  • P protein

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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  • Cite this

    Narayanan, V., Ripepi, B., Jabs, E. W., Hawkins, A., Griffin, C., & Tennekoon, G. (1994). Partial structure and mapping of the human myelin P2 protein gene. Journal of Neurochemistry, 63(6), 2010-2013.