Partial inhibition of hypoxia induced erythropoietin production by cholinergic blockade in the dog

Ernst W Spannhake, J. W. Fisher

Research output: Contribution to journalArticle

Abstract

Anesthetized dogs exposed to hypoxic hypoxia showed elevated plasma erythropoietic activity by 6 hr. This activity was significantly decreased by atropine pretreatment. Methylatropine, a peripheral acting analog of atropine, was equally effective in reducing the erythropoietic response. Neither atropine nor methylatropine, at the doses employed, appeared to exert their effect through blockade at the autonomic ganglia. These studies suggest that the erythropoietic response to short-term hypoxia in the dog involves a peripheral, cholinergically mediated event, perhaps within the kidney itself.

Original languageEnglish (US)
Pages (from-to)19-23
Number of pages5
JournalExperimental Biology and Medicine
Volume156
Issue number1
StatePublished - 1977
Externally publishedYes

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Erythropoietin
Atropine
Cholinergic Agents
Dogs
Autonomic Ganglia
Kidney
Plasmas
Hypoxia
methylatropine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Partial inhibition of hypoxia induced erythropoietin production by cholinergic blockade in the dog. / Spannhake, Ernst W; Fisher, J. W.

In: Experimental Biology and Medicine, Vol. 156, No. 1, 1977, p. 19-23.

Research output: Contribution to journalArticle

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