The present study was designed to examine the possibility of reconstituting the immune system of a patient with AIDS by combining the techniques of repeated adoptive transfer of lymphocytes with bone-marrow transplantation. In these experiments, we studied a patient with AIDS who had a healthy identical twin. Although the patient died and the ultimate goal of the study was not met, definite improvement in the patient's immune function was clearly documented. These efforts have important implications concerning the pathogenesis of AIDS and the potential of this therapeutic approach for the treatment of this invariably fatal disease.
|Original language||English (US)|
|Number of pages||5|
|Journal||New England Journal of Medicine|
|State||Published - 1984|
ASJC Scopus subject areas