Partial immune reconstitution in a patient with the acquired immunodeficiency syndrome

H. C. Lane, H. Masur, D. L. Longo, H. G. Klein, A. H. Rook, G. V. Quinnan, R. G. Steis, A. Macher, G. Whalen, L. C. Edgar

Research output: Contribution to journalArticle

Abstract

The present study was designed to examine the possibility of reconstituting the immune system of a patient with AIDS by combining the techniques of repeated adoptive transfer of lymphocytes with bone-marrow transplantation. In these experiments, we studied a patient with AIDS who had a healthy identical twin. Although the patient died and the ultimate goal of the study was not met, definite improvement in the patient's immune function was clearly documented. These efforts have important implications concerning the pathogenesis of AIDS and the potential of this therapeutic approach for the treatment of this invariably fatal disease.

Original languageEnglish (US)
Pages (from-to)1099-1103
Number of pages5
JournalNew England Journal of Medicine
Volume311
Issue number17
StatePublished - 1984
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Lane, H. C., Masur, H., Longo, D. L., Klein, H. G., Rook, A. H., Quinnan, G. V., Steis, R. G., Macher, A., Whalen, G., & Edgar, L. C. (1984). Partial immune reconstitution in a patient with the acquired immunodeficiency syndrome. New England Journal of Medicine, 311(17), 1099-1103.