Partial epilepsy manifesting atonic seizure: Report of two cases

Takeshi Satow, Akio Ikeda, Junichi Yamamoto, Motohiro Takayama, Masao Matsuhashi, Shinji Ohara, Riki Matsumoto, Tahamina Begum, Hidenao Fukuyama, Nobuo Hashimoto, Hiroshi Shibasaki

Research output: Contribution to journalArticle

Abstract

Purpose: Atonic seizures are commonly seen in patients with generalized epilepsy but only infrequently in patients with partial epilepsy. Clinically generalized atonic seizures as a partial epilepsy have not been studied in detail with video/EEG monitoring. Here we describe the clinical and physiologic characteristics of atonic seizures due to partial epilepsy and discuss the underlying mechanism. Methods: Two patients with partial epilepsy manifesting atonic seizures, one with frontal lobe epilepsy (FLE) and the other with parietal lobe epilepsy (PLE), were reported. The long-term video/EEG monitoring, magnetic resonance imaging (MRI), and interictal fluorodeoxyglucose-positron emission tomography (FDG-PET) were investigated in each patient. Results: Paroxysmal diminution of muscle tone mainly involved the axial muscles in both patients. In contrast with the abrupt falls seen in patients with Lennox-Gastaut syndrome, the falls in these patients were slow, taking 2-5 s to fall down. Ictal EEG records showed low-voltage fast activity in the frontocentral area followed by repetitive spikes at the midline frontocentral area in the patient with FLE, and rhythmic spikes in the left central area in the patient with PLE. Interictal FDG-PET disclosed hypometabolic regions consistent with the clinical and EEG findings. Conclusions: Slow falls might be a feature of atonic seizures in partial epilepsy. Long-lasting atonia in partial epilepsy could be due to either one of the following two possible mechanisms: (a) epileptic activities arising from the negative motor area, of which 50-Hz electric stimulation causes motor inhibition, or (b) sustained atonia with successive electromyogram (EMG) silent periods caused by epileptic discharges arising from the inhibitory area of the primary sensorimotor area.

Original languageEnglish (US)
Pages (from-to)1425-1431
Number of pages7
JournalEpilepsia
Volume43
Issue number11
DOIs
StatePublished - Nov 1 2002
Externally publishedYes

Fingerprint

Partial Epilepsy
Seizures
Electroencephalography
Frontal Lobe Epilepsy
Parietal Lobe
Positron-Emission Tomography
Epilepsy
Generalized Epilepsy
Muscles
Motor Cortex
Electromyography
Electric Stimulation
Stroke
Magnetic Resonance Imaging

Keywords

  • Atonic seizure
  • Negative motor area
  • Partial epilepsy
  • Silent period

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Satow, T., Ikeda, A., Yamamoto, J., Takayama, M., Matsuhashi, M., Ohara, S., ... Shibasaki, H. (2002). Partial epilepsy manifesting atonic seizure: Report of two cases. Epilepsia, 43(11), 1425-1431. https://doi.org/10.1046/j.1528-1157.2002.34501.x

Partial epilepsy manifesting atonic seizure : Report of two cases. / Satow, Takeshi; Ikeda, Akio; Yamamoto, Junichi; Takayama, Motohiro; Matsuhashi, Masao; Ohara, Shinji; Matsumoto, Riki; Begum, Tahamina; Fukuyama, Hidenao; Hashimoto, Nobuo; Shibasaki, Hiroshi.

In: Epilepsia, Vol. 43, No. 11, 01.11.2002, p. 1425-1431.

Research output: Contribution to journalArticle

Satow, T, Ikeda, A, Yamamoto, J, Takayama, M, Matsuhashi, M, Ohara, S, Matsumoto, R, Begum, T, Fukuyama, H, Hashimoto, N & Shibasaki, H 2002, 'Partial epilepsy manifesting atonic seizure: Report of two cases', Epilepsia, vol. 43, no. 11, pp. 1425-1431. https://doi.org/10.1046/j.1528-1157.2002.34501.x
Satow T, Ikeda A, Yamamoto J, Takayama M, Matsuhashi M, Ohara S et al. Partial epilepsy manifesting atonic seizure: Report of two cases. Epilepsia. 2002 Nov 1;43(11):1425-1431. https://doi.org/10.1046/j.1528-1157.2002.34501.x
Satow, Takeshi ; Ikeda, Akio ; Yamamoto, Junichi ; Takayama, Motohiro ; Matsuhashi, Masao ; Ohara, Shinji ; Matsumoto, Riki ; Begum, Tahamina ; Fukuyama, Hidenao ; Hashimoto, Nobuo ; Shibasaki, Hiroshi. / Partial epilepsy manifesting atonic seizure : Report of two cases. In: Epilepsia. 2002 ; Vol. 43, No. 11. pp. 1425-1431.
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AU - Ohara, Shinji

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