Partial dopamine agonist therapy of levodopa-induced dyskinesias

F. Baronti, M. M. Mouradian, K. E. Conant, M. Giuffra, G. Brughitta, Thomas N. Chase

Research output: Contribution to journalArticle

Abstract

We administered the partial dopamine agonist terguride under controlled conditions to patients with Parkinson’s disease (PD), both as monotherapy and in conjunction with intravenous levodopa. Terguride produced a dose-dependent decrease in levodopa-induced dyskinesias (up to 53%) in seven patients without concomitant worsening of parkinsonism, and had no significant antiparkinsonian effect when administered alone. Partial dopamine agonists may hold some promise in the adjuvant therapy of patients with advanced PD.

Original languageEnglish (US)
Pages (from-to)1241-1243
Number of pages3
JournalNeurology
Volume42
Issue number6
StatePublished - Jun 1992

ASJC Scopus subject areas

  • Clinical Neurology

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  • Cite this

    Baronti, F., Mouradian, M. M., Conant, K. E., Giuffra, M., Brughitta, G., & Chase, T. N. (1992). Partial dopamine agonist therapy of levodopa-induced dyskinesias. Neurology, 42(6), 1241-1243.