Partial characterization of an analog of pyridinoline isolated from human skin

M. David Tilson; Robert N. Dreyer; Ann Hudson; Robert J. Cotter; Marvin L. Tanzer

doi:10.1016/0006-291X(85)90316-X

Partial characterization of an analog of pyridinoline isolated from human skin

M. David Tilson, Robert N. Dreyer, Ann Hudson, Robert J. Cotter, Marvin L. Tanzer

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversedphase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.

Original language	English (US)
Pages (from-to)	1222-1227
Number of pages	6
Journal	Biochemical and Biophysical Research Communications
Volume	126
Issue number	3
DOIs	https://doi.org/10.1016/0006-291X(85)90316-X
State	Published - Feb 15 1985

ASJC Scopus subject areas

Biophysics
Biochemistry
Molecular Biology
Cell Biology

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abstract = "The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversedphase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.",

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T1 - Partial characterization of an analog of pyridinoline isolated from human skin

AU - Tilson, M. David

AU - Dreyer, Robert N.

AU - Hudson, Ann

AU - Cotter, Robert J.

AU - Tanzer, Marvin L.

PY - 1985/2/15

Y1 - 1985/2/15

N2 - The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversedphase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.

AB - The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversedphase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.

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Partial characterization of an analog of pyridinoline isolated from human skin

Abstract

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