Partial characterization of an analog of pyridinoline isolated from human skin

M. David Tilson, Robert N. Dreyer, Ann Hudson, Robert J. Cotter, Marvin L. Tanzer

Research output: Contribution to journalArticle

Abstract

The most abundant amine in acid hydrolysates of human skin, eluting in the crosslink region of a reversedphase HPLC chromatogram, has the same retention time as pyridinoline standard. This amine is not pyridinoline, since it is a weak fluorophore and its U V spectrum does not agree with that of pyridinoline. The unknown amine was isolated and characterized by fast atom bombardment mass spectrometry and its structure is consistent with a deoxy-analogue of pyridinoline. It may be a crosslink component of some biological importance, since it is not detectable in skin from a patient with Marfan's Syndrome.

Original languageEnglish (US)
Pages (from-to)1222-1227
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume126
Issue number3
DOIs
StatePublished - Feb 15 1985

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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