Paroxysmal Cold Hemoglobinuria

Satish Shanbhag, Jerry Spivak

Research output: Contribution to journalReview article


Paroxysmal cold hemoglobinuria is a rare cause of autoimmune hemolytic anemia predominantly seen as an acute form in young children after viral illnesses and in a chronic form in some hematological malignancies and tertiary syphilis. It is a complement mediated intravascular hemolytic anemia associated with a biphasic antibody against the P antigen on red cells. The antibody attaches to red cells at colder temperatures and causes red cell lysis when blood recirculates to warmer parts of the body. Treatment is mainly supportive and with red cell transfusion, but immunosuppressive therapy may be effective in severe cases.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalHematology/Oncology Clinics of North America
Issue number3
StatePublished - Jun 1 2015


  • Autoimmune hemolytic anemia
  • Coombs negative hemolysis
  • Donath-Landsteiner
  • PCH
  • Syphilis

ASJC Scopus subject areas

  • Hematology
  • Oncology

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