Paroxetine Retards Disease Onset and Progression in Huntingtin Mutant Mice

Wenzhen Duan, Zhihong Guo, Haiyang Jiang, Bruce Ladenheim, Xiangru Xu, Jean Lud Cadet, Mark P. Mattson

Research output: Contribution to journalArticlepeer-review


We report that administration of paroxetine, a widely prescribed antidepressant drug that acts by inhibiting re-uptake of the neurotransmitter serotonin, suppresses the neurodegenerative process and increases the survival of huntingtin mutant mice, an animal model of Huntington's disease (HD). Paroxetine attenuated motor dysfunction and body weight loss and improved glucose metabolism in the HD mice. Paroxetine was beneficial when treatment was initiated before or after the onset of motor dysfunction, suggesting a potential for such antidepressant drugs in the treatment of presymptomatic and symptomatic HD patients.

Original languageEnglish (US)
Pages (from-to)590-594
Number of pages5
JournalAnnals of neurology
Issue number4
StatePublished - Apr 2004
Externally publishedYes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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