Parkinson's disease: Nigral receptor changes support peptidergic role in nigrostriatal modulation

G. R. Uhl, G. O. Hackney, M. Torchia, V. Stranov, W. W. Tourtellotte, P. J. Whitehouse, V. Tran, S. Strittmatter

Research output: Contribution to journalArticle

Abstract

Autoradiographic studies reveal densities of binding to somatostatin, neurotensin, μ-opiate, and benzodiazepine receptors in substantia nigra specimens from neurologically normal human brains. Binding to nigral angiotensin converting enzyme is also dense, whereas more modest densities of κ-opiate, dopamine, and serotonin receptors are noted. In nigral specimens taken from patients with idiopathic Parkinson's disease, substantial reductions in somatostatin, neurotensin, μ-opiate and κ-opiate receptors contrast with more modest reductions in dopamine and benzodiazepine I receptor subtypes. Angiotensin converting enzyme, serotonin, and benzodiazepine II binding are virtually unaltered. These results underscore the likelihood of strong peptidergic influences on normal and pathologically altered human nigrostriatal circuitry.

Original languageEnglish (US)
Pages (from-to)194-203
Number of pages10
JournalAnnals of Neurology
Volume20
Issue number2
StatePublished - 1986
Externally publishedYes

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Opioid Receptors
Substantia Nigra
Parkinson Disease
Peptidyl-Dipeptidase A
GABA-A Receptors
Somatostatin
Opiate Alkaloids
Neurotensin Receptors
Neurotensin
Serotonin Receptors
Dopamine Receptors
Benzodiazepines
Serotonin
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Uhl, G. R., Hackney, G. O., Torchia, M., Stranov, V., Tourtellotte, W. W., Whitehouse, P. J., ... Strittmatter, S. (1986). Parkinson's disease: Nigral receptor changes support peptidergic role in nigrostriatal modulation. Annals of Neurology, 20(2), 194-203.

Parkinson's disease : Nigral receptor changes support peptidergic role in nigrostriatal modulation. / Uhl, G. R.; Hackney, G. O.; Torchia, M.; Stranov, V.; Tourtellotte, W. W.; Whitehouse, P. J.; Tran, V.; Strittmatter, S.

In: Annals of Neurology, Vol. 20, No. 2, 1986, p. 194-203.

Research output: Contribution to journalArticle

Uhl, GR, Hackney, GO, Torchia, M, Stranov, V, Tourtellotte, WW, Whitehouse, PJ, Tran, V & Strittmatter, S 1986, 'Parkinson's disease: Nigral receptor changes support peptidergic role in nigrostriatal modulation', Annals of Neurology, vol. 20, no. 2, pp. 194-203.
Uhl GR, Hackney GO, Torchia M, Stranov V, Tourtellotte WW, Whitehouse PJ et al. Parkinson's disease: Nigral receptor changes support peptidergic role in nigrostriatal modulation. Annals of Neurology. 1986;20(2):194-203.
Uhl, G. R. ; Hackney, G. O. ; Torchia, M. ; Stranov, V. ; Tourtellotte, W. W. ; Whitehouse, P. J. ; Tran, V. ; Strittmatter, S. / Parkinson's disease : Nigral receptor changes support peptidergic role in nigrostriatal modulation. In: Annals of Neurology. 1986 ; Vol. 20, No. 2. pp. 194-203.
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