Parkinson's disease

depletion of substantia nigra neurotensin receptors

G. R. Uhl, P. J. Whitehouse, D. L. Price, W. W. Tourtelotte, M. J. Kuhar

Research output: Contribution to journalArticle

Abstract

Neurotensin receptor autoradiography reveals dense binding in normal human substantia nigra. In nigra from patients with Parkinson's disease, nigral receptor binding is only about one-third of control values. 'Saturation' analysis suggests that these changes result from receptor loss. These results support a neurotensin-domapine interaction in human nigro-striatal circuits.

Original languageEnglish (US)
Pages (from-to)186-190
Number of pages5
JournalBrain Research
Volume308
Issue number1
DOIs
StatePublished - Aug 6 1984

Fingerprint

Neurotensin Receptors
Substantia Nigra
Parkinson Disease
Corpus Striatum
Neurotensin
Autoradiography

Keywords

  • neurotensin
  • Parkinson's disease
  • peptide
  • receptor autoradiography
  • substantia nigra

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Uhl, G. R., Whitehouse, P. J., Price, D. L., Tourtelotte, W. W., & Kuhar, M. J. (1984). Parkinson's disease: depletion of substantia nigra neurotensin receptors. Brain Research, 308(1), 186-190. https://doi.org/10.1016/0006-8993(84)90935-1

Parkinson's disease : depletion of substantia nigra neurotensin receptors. / Uhl, G. R.; Whitehouse, P. J.; Price, D. L.; Tourtelotte, W. W.; Kuhar, M. J.

In: Brain Research, Vol. 308, No. 1, 06.08.1984, p. 186-190.

Research output: Contribution to journalArticle

Uhl, GR, Whitehouse, PJ, Price, DL, Tourtelotte, WW & Kuhar, MJ 1984, 'Parkinson's disease: depletion of substantia nigra neurotensin receptors', Brain Research, vol. 308, no. 1, pp. 186-190. https://doi.org/10.1016/0006-8993(84)90935-1
Uhl GR, Whitehouse PJ, Price DL, Tourtelotte WW, Kuhar MJ. Parkinson's disease: depletion of substantia nigra neurotensin receptors. Brain Research. 1984 Aug 6;308(1):186-190. https://doi.org/10.1016/0006-8993(84)90935-1
Uhl, G. R. ; Whitehouse, P. J. ; Price, D. L. ; Tourtelotte, W. W. ; Kuhar, M. J. / Parkinson's disease : depletion of substantia nigra neurotensin receptors. In: Brain Research. 1984 ; Vol. 308, No. 1. pp. 186-190.
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