Parkinson's disease and mitochondrial gene variations: A review

Sasan Andalib, Manouchehr Seyedi Vafaee, Albert Gjedde

Research output: Contribution to journalReview articlepeer-review

Abstract

Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More recently, a particular role of mitochondrial dysfunction has been suggested, arising from mitochondrial DNA variations or acquired mutations in PD pathogenesis. The present review summarizes and weighs the evidence in support of mitochondrial DNA (mtDNA) variations as important contributors to the development and course of PD.

Original languageEnglish (US)
Pages (from-to)11-19
Number of pages9
JournalJournal of the Neurological Sciences
Volume346
Issue number1-2
DOIs
StatePublished - Nov 15 2014

Keywords

  • Central nervous system
  • Genetic susceptibility
  • Mitochondrial DNA nucleotide position
  • Mitochondrial DNA variations
  • Mitochondrial dysfunction
  • Parkinson's disease

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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