Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA

S. Kitayama, S. Shimada, G. R. Uhl

Research output: Contribution to journalArticle

Abstract

Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism-inducing neurotoxin metabolite MPP+ (1-methyl-4-phenylpyridinium) avidly, and MPP+ toxicity results. By documenting that the dopamine transporter can confer MPP+ sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.

Original languageEnglish (US)
Pages (from-to)109-111
Number of pages3
JournalAnnals of Neurology
Volume32
Issue number1
StatePublished - Jul 1992

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA'. Together they form a unique fingerprint.

  • Cite this