Abstract
A variety of mutations in parkin are linked to autosomal recessive Parkinson's disease (PD). Mutations in parkin may be one of the most common causes of autosomal recessive PD. Parkin is an E3 ubiquitin-protein ligase and familial associated mutations disrupt the E3 ligase activity, thus implicating derangements in the ubiquitin proteasomal pathway in the pathogenesis of PD. We review the clinical and neuropathological features of Parkinson's disease caused by parkin mutations. In addition, we discuss the emerging evidence that parkin is an E3 ubiquitin-protein ligase and how derangements in its E3 ligase activity might cause autosomal recessive PD.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 467-482 |
| Number of pages | 16 |
| Journal | Clinical Neuroscience Research |
| Volume | 1 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2001 |
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Keywords
- α-Synuclein
- Dopamine
- Neurodegeneration
- Proteasome
- Ubiquitin
- Ubiquitinization
- UCHL-1
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry
- Neurology
- Neuropsychology and Physiological Psychology
Cite this
Parkin : Clinical aspects and neurobiology. / Zhang, Yi; Dawson, Valina; Dawson, Ted M.
In: Clinical Neuroscience Research, Vol. 1, No. 6, 12.2001, p. 467-482.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Parkin
T2 - Clinical aspects and neurobiology
AU - Zhang, Yi
AU - Dawson, Valina
AU - Dawson, Ted M
PY - 2001/12
Y1 - 2001/12
N2 - A variety of mutations in parkin are linked to autosomal recessive Parkinson's disease (PD). Mutations in parkin may be one of the most common causes of autosomal recessive PD. Parkin is an E3 ubiquitin-protein ligase and familial associated mutations disrupt the E3 ligase activity, thus implicating derangements in the ubiquitin proteasomal pathway in the pathogenesis of PD. We review the clinical and neuropathological features of Parkinson's disease caused by parkin mutations. In addition, we discuss the emerging evidence that parkin is an E3 ubiquitin-protein ligase and how derangements in its E3 ligase activity might cause autosomal recessive PD.
AB - A variety of mutations in parkin are linked to autosomal recessive Parkinson's disease (PD). Mutations in parkin may be one of the most common causes of autosomal recessive PD. Parkin is an E3 ubiquitin-protein ligase and familial associated mutations disrupt the E3 ligase activity, thus implicating derangements in the ubiquitin proteasomal pathway in the pathogenesis of PD. We review the clinical and neuropathological features of Parkinson's disease caused by parkin mutations. In addition, we discuss the emerging evidence that parkin is an E3 ubiquitin-protein ligase and how derangements in its E3 ligase activity might cause autosomal recessive PD.
KW - α-Synuclein
KW - Dopamine
KW - Neurodegeneration
KW - Proteasome
KW - Ubiquitin
KW - Ubiquitinization
KW - UCHL-1
UR - http://www.scopus.com/inward/record.url?scp=0012641135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0012641135&partnerID=8YFLogxK
U2 - 10.1016/S1566-2772(01)00025-1
DO - 10.1016/S1566-2772(01)00025-1
M3 - Article
AN - SCOPUS:0012641135
VL - 1
SP - 467
EP - 482
JO - Clinical Neuroscience Research
JF - Clinical Neuroscience Research
SN - 1566-2772
IS - 6
ER -