Parkin and Hsp70 sacked by BAG5

Kenny K.K. Chung, Ted M. Dawson

Research output: Contribution to journalReview article

Abstract

Loss-of-function mutations in the parkin gene, which encodes an E3 ubiquitin ligase, are the major cause of early-onset Parkinson's disease (PD). In this issue of Neuron, Kalia et al. show that the bcl-2-associated athanogene 5 (BAG5) enhances dopamine neuron death in an in vivo model of PD through inhibiting the E3 ligase activity of parkin and the chaperone activity of Hsp70.

Original languageEnglish (US)
Pages (from-to)899-901
Number of pages3
JournalNeuron
Volume44
Issue number6
DOIs
StatePublished - Dec 16 2004

ASJC Scopus subject areas

  • Neuroscience(all)

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