PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

Research output: Contribution to journalArticle

Abstract

Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.

Original languageEnglish (US)
Pages (from-to)573-574
Number of pages2
JournalAutophagy
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Drp1
  • Mitochondrial dynamics
  • Mitochondrial homeostasis
  • Mitophagy
  • Parkin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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