PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

Research output: Contribution to journalArticlepeer-review

Abstract

Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.

Original languageEnglish (US)
Pages (from-to)573-574
Number of pages2
JournalAutophagy
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2015

Keywords

  • Drp1
  • Mitochondrial dynamics
  • Mitochondrial homeostasis
  • Mitophagy
  • Parkin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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