PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

Research output: Contribution to journalArticle

Abstract

Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.

Original languageEnglish (US)
Pages (from-to)573-574
Number of pages2
JournalAutophagy
Volume11
Issue number3
DOIs
StatePublished - Jan 1 2015

Fingerprint

Mitochondrial Degradation
Mitochondrial Dynamics
Dynamins
Ubiquitin-Protein Ligases
Cardiovascular Diseases
Health
Brain
Proteins

Keywords

  • Drp1
  • Mitochondrial dynamics
  • Mitochondrial homeostasis
  • Mitophagy
  • Parkin

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

PARK2/Parkin becomes critical when DNM1L/Drp1 is absent. / Roy, Madhuparna; Kageyama, Yusuke; Iijima, Miho; Sesaki, Hiromi.

In: Autophagy, Vol. 11, No. 3, 01.01.2015, p. 573-574.

Research output: Contribution to journalArticle

@article{eda37366f9624bf5b0bac198308879a3,
title = "PARK2/Parkin becomes critical when DNM1L/Drp1 is absent",
abstract = "Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.",
keywords = "Drp1, Mitochondrial dynamics, Mitochondrial homeostasis, Mitophagy, Parkin",
author = "Madhuparna Roy and Yusuke Kageyama and Miho Iijima and Hiromi Sesaki",
year = "2015",
month = "1",
day = "1",
doi = "10.1080/15548627.2015.1017193",
language = "English (US)",
volume = "11",
pages = "573--574",
journal = "Autophagy",
issn = "1554-8627",
publisher = "Landes Bioscience",
number = "3",

}

TY - JOUR

T1 - PARK2/Parkin becomes critical when DNM1L/Drp1 is absent

AU - Roy, Madhuparna

AU - Kageyama, Yusuke

AU - Iijima, Miho

AU - Sesaki, Hiromi

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.

AB - Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.

KW - Drp1

KW - Mitochondrial dynamics

KW - Mitochondrial homeostasis

KW - Mitophagy

KW - Parkin

UR - http://www.scopus.com/inward/record.url?scp=84943764944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84943764944&partnerID=8YFLogxK

U2 - 10.1080/15548627.2015.1017193

DO - 10.1080/15548627.2015.1017193

M3 - Article

C2 - 25715097

AN - SCOPUS:84943764944

VL - 11

SP - 573

EP - 574

JO - Autophagy

JF - Autophagy

SN - 1554-8627

IS - 3

ER -