Abstract
Maintaining mitochondrial dynamics and proper execution of mitophagy is crucial for sustaining cellular health. Defects in these processes have been linked to cardiovascular diseases and neurodegeneration. In a recent publication, we reported that the mitochondrial division dynamin protein DNM1L/ Drp1 and the E3 ubiquitin ligase PARK2/Parkin work in a synergistic manner to maintain mitochondrial function and structural integrity in the mouse heart and brain.
Original language | English (US) |
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Pages (from-to) | 573-574 |
Number of pages | 2 |
Journal | Autophagy |
Volume | 11 |
Issue number | 3 |
DOIs | |
State | Published - Jan 1 2015 |
Keywords
- Drp1
- Mitochondrial dynamics
- Mitochondrial homeostasis
- Mitophagy
- Parkin
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology