Parietal-eye phototransduction components and their potential evolutionary implications

Chih Ying Su, Dong Gen Luo, Akihisa Terakita, Yoshinori Shichida, Hsi Wen Liao, Manija A. Kazmi, Thomas P. Sakmar, King-Wai Yau

Research output: Contribution to journalArticle

Abstract

The parietal-eye photoreceptor is unique because it has two antagonistic light signaling pathways in the same cell-a hyperpolarizing pathway maximally sensitive to blue light and a depolarizing pathway maximally sensitive to green light. Here, we report the molecular components of these two pathways. We found two opsins in the same cell: the blue-sensitive pinopsin and a previously unidentified green-sensitive opsin, which we name parietopsin. Signaling components included gustducin-α and Gαo, but not rod or cone transducin-α. Single-cell recordings demonstrated that Go mediates the depolarizing response. Gustducin-α resembles transducin-α functionally and likely mediates the hyperpolarizing response. The parietopsin-Go signaling pair provides clues about how rod and cone phototransduction might have evolved.

Original languageEnglish (US)
Pages (from-to)1617-1621
Number of pages5
JournalScience
Volume311
Issue number5767
DOIs
StatePublished - Mar 17 2006

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Light Signal Transduction
Transducin
Vertebrate Photoreceptor Cells
Opsins
Methyl Green
Light
Names
gustducin

ASJC Scopus subject areas

  • General

Cite this

Su, C. Y., Luo, D. G., Terakita, A., Shichida, Y., Liao, H. W., Kazmi, M. A., ... Yau, K-W. (2006). Parietal-eye phototransduction components and their potential evolutionary implications. Science, 311(5767), 1617-1621. https://doi.org/10.1126/science.1123802

Parietal-eye phototransduction components and their potential evolutionary implications. / Su, Chih Ying; Luo, Dong Gen; Terakita, Akihisa; Shichida, Yoshinori; Liao, Hsi Wen; Kazmi, Manija A.; Sakmar, Thomas P.; Yau, King-Wai.

In: Science, Vol. 311, No. 5767, 17.03.2006, p. 1617-1621.

Research output: Contribution to journalArticle

Su, CY, Luo, DG, Terakita, A, Shichida, Y, Liao, HW, Kazmi, MA, Sakmar, TP & Yau, K-W 2006, 'Parietal-eye phototransduction components and their potential evolutionary implications', Science, vol. 311, no. 5767, pp. 1617-1621. https://doi.org/10.1126/science.1123802
Su CY, Luo DG, Terakita A, Shichida Y, Liao HW, Kazmi MA et al. Parietal-eye phototransduction components and their potential evolutionary implications. Science. 2006 Mar 17;311(5767):1617-1621. https://doi.org/10.1126/science.1123802
Su, Chih Ying ; Luo, Dong Gen ; Terakita, Akihisa ; Shichida, Yoshinori ; Liao, Hsi Wen ; Kazmi, Manija A. ; Sakmar, Thomas P. ; Yau, King-Wai. / Parietal-eye phototransduction components and their potential evolutionary implications. In: Science. 2006 ; Vol. 311, No. 5767. pp. 1617-1621.
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