Parietal-eye phototransduction components and their potential evolutionary implications

Chih Ying Su, Dong Gen Luo, Akihisa Terakita, Yoshinori Shichida, Hsi Wen Liao, Manija A. Kazmi, Thomas P. Sakmar, King Wai Yau

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Abstract

The parietal-eye photoreceptor is unique because it has two antagonistic light signaling pathways in the same cell-a hyperpolarizing pathway maximally sensitive to blue light and a depolarizing pathway maximally sensitive to green light. Here, we report the molecular components of these two pathways. We found two opsins in the same cell: the blue-sensitive pinopsin and a previously unidentified green-sensitive opsin, which we name parietopsin. Signaling components included gustducin-α and Gαo, but not rod or cone transducin-α. Single-cell recordings demonstrated that Go mediates the depolarizing response. Gustducin-α resembles transducin-α functionally and likely mediates the hyperpolarizing response. The parietopsin-Go signaling pair provides clues about how rod and cone phototransduction might have evolved.

Original languageEnglish (US)
Pages (from-to)1617-1621
Number of pages5
JournalScience
Volume311
Issue number5767
DOIs
StatePublished - Mar 17 2006

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ASJC Scopus subject areas

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Cite this

Su, C. Y., Luo, D. G., Terakita, A., Shichida, Y., Liao, H. W., Kazmi, M. A., Sakmar, T. P., & Yau, K. W. (2006). Parietal-eye phototransduction components and their potential evolutionary implications. Science, 311(5767), 1617-1621. https://doi.org/10.1126/science.1123802