Parietal cell antibodies among peruvians with gastric pathologic changes

I. C. Kohlstadt, E. A Antunez de Mayolo, Robert H Gilman, R. Leon-Barua, A. Ramirez-Ramos, C. Rodriguez, S. Recavarren, W. Spira, J. Watanabe, R. Berenson, C. Guevara, J. Palomino, M. Alvarez, J. Cok, C. Ramirez-Icaza

Research output: Contribution to journalArticle

Abstract

Parietal cell antibodies were present in 12% of 272 Peruvians presenting for endoscopy. Gender, age, socioeconomic status, ethnic background (Peruvian versus Japanese), and altitude at which the patient lived were not associated with the presence of parietal cell antibodies. No significant relationship could be shown between the presence of parietal cell antibodies and either Helicobacter pylori infection or gastric lesions, including chronic atrophic gastritis. Loss of proper gastric glands was significantly more common in patients who had H. pylori infection than in those in whom no H, pylori was found on biopsy (78 of 114 (85% versus 14 of 36 (39%; p = 0.002). Our data suggest that, although parietal cell antibodies are present in third-world populations, they are unrelated to H. pylori infection and that pathologic changes associated with this infection are not mediated by the action of parietal cell antibodies on the cells of the stomach.

Original languageEnglish (US)
Pages (from-to)973-977
Number of pages5
JournalScandinavian Journal of Gastroenterology
Volume28
Issue number11
DOIs
StatePublished - 1993

Fingerprint

Stomach
Antibodies
Helicobacter Infections
Helicobacter pylori
Atrophic Gastritis
Pylorus
Gastric Mucosa
Social Class
Endoscopy
Biopsy
Infection
Population

Keywords

  • Autoimmunity
  • Developing country
  • Gastric cancer
  • Gastritis
  • Helicobacter pylori
  • High altitude
  • Parietal cell antibodies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Kohlstadt, I. C., de Mayolo, E. A. A., Gilman, R. H., Leon-Barua, R., Ramirez-Ramos, A., Rodriguez, C., ... Ramirez-Icaza, C. (1993). Parietal cell antibodies among peruvians with gastric pathologic changes. Scandinavian Journal of Gastroenterology, 28(11), 973-977. https://doi.org/10.3109/00365529309098294

Parietal cell antibodies among peruvians with gastric pathologic changes. / Kohlstadt, I. C.; de Mayolo, E. A Antunez; Gilman, Robert H; Leon-Barua, R.; Ramirez-Ramos, A.; Rodriguez, C.; Recavarren, S.; Spira, W.; Watanabe, J.; Berenson, R.; Guevara, C.; Palomino, J.; Alvarez, M.; Cok, J.; Ramirez-Icaza, C.

In: Scandinavian Journal of Gastroenterology, Vol. 28, No. 11, 1993, p. 973-977.

Research output: Contribution to journalArticle

Kohlstadt, IC, de Mayolo, EAA, Gilman, RH, Leon-Barua, R, Ramirez-Ramos, A, Rodriguez, C, Recavarren, S, Spira, W, Watanabe, J, Berenson, R, Guevara, C, Palomino, J, Alvarez, M, Cok, J & Ramirez-Icaza, C 1993, 'Parietal cell antibodies among peruvians with gastric pathologic changes', Scandinavian Journal of Gastroenterology, vol. 28, no. 11, pp. 973-977. https://doi.org/10.3109/00365529309098294
Kohlstadt, I. C. ; de Mayolo, E. A Antunez ; Gilman, Robert H ; Leon-Barua, R. ; Ramirez-Ramos, A. ; Rodriguez, C. ; Recavarren, S. ; Spira, W. ; Watanabe, J. ; Berenson, R. ; Guevara, C. ; Palomino, J. ; Alvarez, M. ; Cok, J. ; Ramirez-Icaza, C. / Parietal cell antibodies among peruvians with gastric pathologic changes. In: Scandinavian Journal of Gastroenterology. 1993 ; Vol. 28, No. 11. pp. 973-977.
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