@article{1dfee85a1b15487faa34c7da5f0221b3,
title = "Parenteral trimethoprim-sulfamethoxazole and carbenicillin as empiric therapy for neutropenic patients with cancer",
abstract = "A combination of parenteral trimethoprim-sulfamethoxazole and carbenicillin (TMPSMZ- C) was compared with a gentamicin and carbenicillin combination (G-C) as empiric therapy for the febrile neutropenic patient with cancer in a prospective doubleblind trial. Target plasma levels of TMP were achieved easily. When all trials were considered, TMP-SMZ-C was more effective (P ⩽ 0.045) than G-C. When only proven infections were considered, the two regimens were equally effective. Adverse effects of both regimens were similar. Experience with infections due to individual organisms, particularly Pseudomonas aeruginosa and Staphylococcus aureus, was limited. General recommendations for use of TMP-SMZ-C in this patient population cannot be made until more comprehensive studies are done.",
author = "Braine, {Hayden G.} and Stuart, {Robert K.} and Rein Saral and Lietman, {Paul S.}",
note = "Funding Information: This work was supported in part by the grant no. CA-06973 from the National Institutes of Health-National Cancer Institute, U.S. Public Health Service, and by a grant from Roche Laboratories, Division of Hoffmann-LaRoche, Nutley, New Jersey. This study was made possible by the assistance of the staff of the satellite Pharmacy and Nursing Service of The Johns Hopkins Oncology Center and the cooperation of house officers of the Department of Medicine and Pediatrics of The Johns Hopkins Hospital. We are indebted to Stephen Baust, Chris Angelopulos, Dean Harrison, and Donald Fuller for specimen procurement and to Bruce Thompson for statistical analysis. The expert assistance of Wanda Novak was invaluable in manuscript preparation. Please address requests for reprints to Dr. H. G. Braine, Room 137 Oncology, The Johns Hopkins Hospital, 600 N. Wolfe Street, Baltimore, Maryland 21205.",
year = "1982",
month = mar,
doi = "10.1093/clinids/4.2.586",
language = "English (US)",
volume = "4",
pages = "586--592",
journal = "Reviews of infectious diseases",
issn = "0162-0886",
publisher = "Oxford University Press",
number = "2",
}