Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study

Majella Byrne, Esben Agerbo, William W Eaton, Preben Bo Mortensen

Research output: Contribution to journalArticle

Abstract

Background. We examined the relationships between measures of parental and personal socio-economic status and risk of first admission with schizophrenia in order to identify whether low socio-economic status in cases is a consequence of the illness process or is a familial risk factor. Methods. A national population-based nested case-control study based on Danish longitudinal registers was conducted. The sample included 7704 first admissions with ICD-8 or ICD-10 schizophrenia admitted to a psychiatric facility in Denmark between 1981 and 1998 and 192 590 individually time-, age- and gender-matched population controls identified through national registers, and their parents and siblings. Socio-economic indicators measured in the year prior to admission and background factors for cases, controls, and parents were included. Results. Risk of schizophrenia was associated with unemployment, low educational attainment, being single, lower wealth status, low income, and being childless. Increased risk was associated with a family history of psychiatric disorders, birth in urban areas, birth outside of Denmark, and having three of more siblings. Increased risk of schizophrenia was associated with parental unemployment and parental lower income, but was not associated with parental wealth. Risk for schizophrenia was associated with higher education in parents. Conclusions. Increased risk of first admission was associated with socio-economic disadvantage in cases. Although we found some associations between parental unemployment and parental higher education and risk of schizophrenia, there was little evidence that low parental socio-economic status increases the risk of schizophrenia.

Original languageEnglish (US)
Pages (from-to)87-96
Number of pages10
JournalSocial Psychiatry and Psychiatric Epidemiology
Volume39
Issue number2
DOIs
StatePublished - Feb 2004

Fingerprint

schizophrenia
Schizophrenia
Economics
Unemployment
economics
unemployment
Parents
parents
Denmark
Psychiatry
Siblings
Parturition
low income
Education
Population Control
International Classification of Diseases
genealogy
Case-Control Studies
education
urban area

Keywords

  • Epidemiology
  • First admission
  • Nested case-control design
  • Parental socio-economic status
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study. / Byrne, Majella; Agerbo, Esben; Eaton, William W; Mortensen, Preben Bo.

In: Social Psychiatry and Psychiatric Epidemiology, Vol. 39, No. 2, 02.2004, p. 87-96.

Research output: Contribution to journalArticle

@article{204f542e00c14720b0fcb8b3f2f12f26,
title = "Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study",
abstract = "Background. We examined the relationships between measures of parental and personal socio-economic status and risk of first admission with schizophrenia in order to identify whether low socio-economic status in cases is a consequence of the illness process or is a familial risk factor. Methods. A national population-based nested case-control study based on Danish longitudinal registers was conducted. The sample included 7704 first admissions with ICD-8 or ICD-10 schizophrenia admitted to a psychiatric facility in Denmark between 1981 and 1998 and 192 590 individually time-, age- and gender-matched population controls identified through national registers, and their parents and siblings. Socio-economic indicators measured in the year prior to admission and background factors for cases, controls, and parents were included. Results. Risk of schizophrenia was associated with unemployment, low educational attainment, being single, lower wealth status, low income, and being childless. Increased risk was associated with a family history of psychiatric disorders, birth in urban areas, birth outside of Denmark, and having three of more siblings. Increased risk of schizophrenia was associated with parental unemployment and parental lower income, but was not associated with parental wealth. Risk for schizophrenia was associated with higher education in parents. Conclusions. Increased risk of first admission was associated with socio-economic disadvantage in cases. Although we found some associations between parental unemployment and parental higher education and risk of schizophrenia, there was little evidence that low parental socio-economic status increases the risk of schizophrenia.",
keywords = "Epidemiology, First admission, Nested case-control design, Parental socio-economic status, Schizophrenia",
author = "Majella Byrne and Esben Agerbo and Eaton, {William W} and Mortensen, {Preben Bo}",
year = "2004",
month = "2",
doi = "10.1007/s00127-004-0715-y",
language = "English (US)",
volume = "39",
pages = "87--96",
journal = "Social Psychiatry and Psychiatric Epidemiology",
issn = "0933-7954",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

TY - JOUR

T1 - Parental socio-economic status and risk of first admission with schizophrenia - A Danish national register based study

AU - Byrne, Majella

AU - Agerbo, Esben

AU - Eaton, William W

AU - Mortensen, Preben Bo

PY - 2004/2

Y1 - 2004/2

N2 - Background. We examined the relationships between measures of parental and personal socio-economic status and risk of first admission with schizophrenia in order to identify whether low socio-economic status in cases is a consequence of the illness process or is a familial risk factor. Methods. A national population-based nested case-control study based on Danish longitudinal registers was conducted. The sample included 7704 first admissions with ICD-8 or ICD-10 schizophrenia admitted to a psychiatric facility in Denmark between 1981 and 1998 and 192 590 individually time-, age- and gender-matched population controls identified through national registers, and their parents and siblings. Socio-economic indicators measured in the year prior to admission and background factors for cases, controls, and parents were included. Results. Risk of schizophrenia was associated with unemployment, low educational attainment, being single, lower wealth status, low income, and being childless. Increased risk was associated with a family history of psychiatric disorders, birth in urban areas, birth outside of Denmark, and having three of more siblings. Increased risk of schizophrenia was associated with parental unemployment and parental lower income, but was not associated with parental wealth. Risk for schizophrenia was associated with higher education in parents. Conclusions. Increased risk of first admission was associated with socio-economic disadvantage in cases. Although we found some associations between parental unemployment and parental higher education and risk of schizophrenia, there was little evidence that low parental socio-economic status increases the risk of schizophrenia.

AB - Background. We examined the relationships between measures of parental and personal socio-economic status and risk of first admission with schizophrenia in order to identify whether low socio-economic status in cases is a consequence of the illness process or is a familial risk factor. Methods. A national population-based nested case-control study based on Danish longitudinal registers was conducted. The sample included 7704 first admissions with ICD-8 or ICD-10 schizophrenia admitted to a psychiatric facility in Denmark between 1981 and 1998 and 192 590 individually time-, age- and gender-matched population controls identified through national registers, and their parents and siblings. Socio-economic indicators measured in the year prior to admission and background factors for cases, controls, and parents were included. Results. Risk of schizophrenia was associated with unemployment, low educational attainment, being single, lower wealth status, low income, and being childless. Increased risk was associated with a family history of psychiatric disorders, birth in urban areas, birth outside of Denmark, and having three of more siblings. Increased risk of schizophrenia was associated with parental unemployment and parental lower income, but was not associated with parental wealth. Risk for schizophrenia was associated with higher education in parents. Conclusions. Increased risk of first admission was associated with socio-economic disadvantage in cases. Although we found some associations between parental unemployment and parental higher education and risk of schizophrenia, there was little evidence that low parental socio-economic status increases the risk of schizophrenia.

KW - Epidemiology

KW - First admission

KW - Nested case-control design

KW - Parental socio-economic status

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=2142703868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142703868&partnerID=8YFLogxK

U2 - 10.1007/s00127-004-0715-y

DO - 10.1007/s00127-004-0715-y

M3 - Article

VL - 39

SP - 87

EP - 96

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

SN - 0933-7954

IS - 2

ER -