Parental reports on early language and motor milestones in fragile X syndrome with and without autism spectrum disorders

Rebecca Hinton, Dejan B. Budimirovic, Peter B. Marschik, Victor B. Talisa, Christa Einspieler, Tanjala Gipson, Michael V. Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: This study examined features of early language and motor milestones in children with fragile X syndrome (FXS) and contrasted these features with a diagnosis of Autism Spectrum Disorder (ASD) later in life in these children. Methods: We retrospectively examined parental report of age of onset for walking and first words for primarily boys with FXS, both with ASD (FXS±ASD) and FXS-only. The diagnosis of ASD was established by DSM-IV criteria, which were complemented by the ADOS. The age of onset was analyzed as a continuous and categorical variable, which were compared to the upper limit of typically developing children. Results: Individuals with FXS-only are more delayed in the onset of first words than first walks. The finding represents a pattern suggesting a continuum as robustly demonstrated in individuals with FXS±ASD vs. FXS-only. Conclusion: Our results support validity of FXS±ASD co-morbidity as a distinct phenotype in individuals with FXS.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalDevelopmental Neurorehabilitation
Volume16
Issue number1
DOIs
StatePublished - 2013

Keywords

  • Autism
  • autism spectrum disorders
  • fragile X
  • language
  • milestones
  • motor development
  • questionnaire

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Rehabilitation
  • Developmental Neuroscience

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