Parental history of psychiatric diagnoses and unipolar depression: A Danish National Register-based cohort study

K. L. Musliner, B. B. Trabjerg, B. L. Waltoft, T. M. Laursen, P. B. Mortensen, P. P. Zandi, T. Munk-Olsen

Research output: Contribution to journalArticle

Abstract

Background Depression is known to run in families, but the effects of parental history of other psychiatric diagnoses on depression rates are less well studied. Few studies have examined the impact of parental psychopathology on depression rates in older age groups. Method We established a population-based cohort including all individuals born in Denmark after 1954 and alive on their 10th birthday (N = 29 76 264). Exposure variables were maternal and paternal history of schizophrenia, bipolar disorder, depression, anxiety or 'other' psychiatric diagnoses. Incidence rate ratios (IRRs) were estimated using Poisson regressions. Results Parental history of any psychiatric diagnosis increased incidence rates of outpatient (maternal: IRR 1.88, p < 0.0001; paternal: IRR 1.68, p < 0.0001) and inpatient (maternal: IRR 1.99, p < 0.0001; paternal: IRR 1.83, p < 0.0001) depression relative to no parental history. IRRs for parental history of non-affective disorders remained relatively stable across age groups, while IRRs for parental affective disorders (unipolar or bipolar) decreased with age from 2.29-3.96 in the youngest age group to 1.53-1.90 in the oldest group. IRR estimates for all parental diagnoses were similar among individuals aged '

Original languageEnglish (US)
Pages (from-to)2781-2791
Number of pages11
JournalPsychological medicine
Volume45
Issue number13
DOIs
StatePublished - Oct 11 2015

Keywords

  • Parental history
  • register-based research
  • survival analysis
  • unipolar depression

ASJC Scopus subject areas

  • Applied Psychology
  • Psychiatry and Mental health

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    Musliner, K. L., Trabjerg, B. B., Waltoft, B. L., Laursen, T. M., Mortensen, P. B., Zandi, P. P., & Munk-Olsen, T. (2015). Parental history of psychiatric diagnoses and unipolar depression: A Danish National Register-based cohort study. Psychological medicine, 45(13), 2781-2791. https://doi.org/10.1017/S0033291715000744